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AutorGalhardo, Maria Clara Gutierrez
AutorOliveira, Rosely Maria Zancopé de
AutorValle, Antonio Carlos Francesconi do
AutorPaes, Rodrigo de Almeida
AutorTavares, Patricia Morais e Silva
AutorMonzon, Araceli
AutorMellado, Emilia
AutorRodriguez-Tudela, Juan L.
AutorCuenca-Estrella, Manuel
Fecha de acceso2019-05-29T13:05:21Z
Fecha de disponibilización2019-05-29T13:05:21Z
Fecha de publicación2008
ReferenciaGALHARDO, Maria Clara Gutierrez et al. Molecular epidemiology and antifungal susceptibility patterns of Sporothrix schenckii isolates from a cat-transmitted epidemic of sporotrichosis in Rio de Janeiro, Brazil. Medical Mycology, v. 46, p. 141-151, 2008.pt_BR
ISSN1369-3786pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/33263
Idiomaengpt_BR
EditorOxford University Presspt_BR
Derechos de autoropen accesspt_BR
TítuloMolecular epidemiology and antifungal susceptibility patterns of Sporothrix schenckii isolates from a cat-transmitted epidemic of sporotrichosis in Rio de Janeiro, Brazilpt_BR
Tipo del documentoArticlept_BR
DOI10.1080/13693780701742399
Resumen en InglésSince 1998 a cat-transmitted epidemic of sporotrichosis has been observed in Rio de Janeiro (RJ), Brazil. Besides the lymphocutaneous and fixed forms, other presentations, such as disseminated cutaneous and mucosal involvement, as well as for the first time, erythema nodosum and erythema multiforme have been reported associated with sporotrichosis. This study investigates the phenotypes and genotypes of Sporothrix schenckii isolates recovered from different clinical forms of the disease noted as part of this epidemic. A total of 88 isolates recovered from 59 cases associated with the epidemic and 29 controls (from cases in other Brazilian regions and Spain) were included in this study. In vitro susceptibility testing was conducted as part of the phenotypic analysis, while the genotypic analysis involved a DNA fingerprinting method with primer M13 and ribosomal DNA sequencing of the internal transcribed spacer (ITS). MIC values of amphotericin B, itraconazole, posaconazole, ravuconazole, and terbinafine were found to be significantly lower (P<0.01) for isolates associated with the epidemic than for control strains. No differences in MIC values were observed related to clinical forms of the infection. Fingerprinting analysis showed that RJ epidemic strains were genetically related. Although nine subtypes were found, they were not associated with specific clinical forms. Similar results were obtained with the ITS sequence analysis. These data suggest that the strains isolated from the epidemic cases of sporotrichosis in RJ all originated from a common source.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Infectologia. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Micologia. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Infectologia. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Micologia. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Micologia. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónInstituto de Salud Carlos III. Centro Nacional de Microbiología. Servicio de Micología. Madrid, Spain.pt_BR
AfiliaciónInstituto de Salud Carlos III. Centro Nacional de Microbiología. Servicio de Micología. Madrid, Spain.pt_BR
AfiliaciónInstituto de Salud Carlos III. Centro Nacional de Microbiología. Servicio de Micología. Madrid, Spain.pt_BR
AfiliaciónInstituto de Salud Carlos III. Centro Nacional de Microbiología. Servicio de Micología. Madrid, Spain.pt_BR
Palavras clave en InglêsSporothrix schenckiipt_BR
Palavras clave en InglêsIn vitro susceptibilitypt_BR
Palavras clave en InglêsPCR fingerprintingpt_BR
Palavras clave en InglêsClinical formspt_BR
Palavras clave en InglêsITS regionpt_BR
e-ISSN1460-2709
Fecha de embargo2020-05-29


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