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2020-06-13
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EFFECTIVENESS OF DIRECT-ACTING AGENTS FOR HEPATITIS C AND LIVER STIFFNESS CHANGING AFTER SUSTAINED VIROLOGICAL RESPONSE
Fernandes, Flavia F. et al. | Date Issued: 2019
Author
Fernandes, Flavia F.
Piedade, Juliana
Guimaraes, Livia
Nunes, Estevao P.
Chaves, Ursula B.
Goldenzon, Rafaela V.
Cardoso, Sandra W.
Duarte, Joana
Grinsztejn, Beatriz
Veloso, Valdiléa G.
Pereira, Gustavo
Perazzo, Hugo
Affilliation
Bonsucesso Federal Hospital. Gastroenterology Department. Rio de Janeiro, RJ, Brazil.
Bonsucesso Federal Hospital. Gastroenterology Department. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil.
Bonsucesso Federal Hospital. Gastroenterology Department. Rio de Janeiro, RJ, Brazil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil.
Bonsucesso Federal Hospital. Gastroenterology Department. Rio de Janeiro, RJ, Brazil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil.
Bonsucesso Federal Hospital. Gastroenterology Department. Rio de Janeiro, RJ, Brazil / Estácio de Sá University. Rio de Janeiro, RJ, Brazil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil.
Abstract
Few studies have evaluated sustained virological response (SVR) rates by direct antivirals (DAAs) and liver stiffness measurement (LSM) changing post-SVR in limited-resource settings. We aimed to describe the effectiveness of DAAs for HCV treatment and to assess the changing of LSM post-SVR METHODS: This retrospective study analyzed data of consecutive HCV-infected patients treated by DAAs from 2015 to 2017 in two tertiary centers in Brazil. SVR rates were reported by intention-to-treat (ITT) and per-protocol analysis. LSM by transient elastography performed before treatment and post-SVR were compared and logistic regression models were performed.
Keywords
Hepatitis C
Liver stiffness
Virological response
 
Publisher
Wiley
Citation
FERNANDES, Flavia F. et al. Effectiveness of direct-acting agents for hepatitis C and liver stiffness changing after sustained virological response. Journal of Gastroenterology and Hepatology, p. 1-24, May 2019.
DOI
10.1111/jgh.14707
ISSN
0815-9319