Please use this identifier to cite or link to this item:
https://www.arca.fiocruz.br/handle/icict/33501
Type
ArticleCopyright
Restricted access
Embargo date
2022-01-01
Collections
- IOC - Artigos de Periódicos [12500]
Metadata
Show full item record
LABORATORY DIAGNOSIS OF HEPATITIS A
Paula, Vanessa Salete de | Date Issued:
2012
Author
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ. Brasil.
Abstract
The diagnostic gold standard for hepatitis A is the detection of anti-hepatitis A
virus (HAV) IgM antibodies and the determination of total anti-HAV by enzyme
immunoassay. However, detection of HAV RNA can be useful in the diagnosis of
patients without specific antibodies for hepatitis A and for the monitoring of
infection. Studies using real-time PCR have demonstrated that HAV RNA can be
detected not only in feces, but also in serum and saliva samples earlier than
detection of antibodies, and that viremia may be present for a much longer
period than the convalescent phase of hepatitis A. Alternative samples have
been proposed for diagnosis, epidemiological studies, investigation of outbreaks
and selection of persons receptive to vaccination. Understanding the events of
clinical course that take place during the hepatitis A infection may lead to more
effective diagnosis.
Share