Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/33777
Title: Nectomys Squamipes (Rodentia: Cricetidae) as an experimental model for Schistosomiasis Mansoni
Authors: Souza, Valéria Aguiar Mello de
Silva, Rosângela Rodrigues e
Maldonado Jr., Arnaldo
Silva, José Roberto Machado e
Rey, Luis
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Biologia. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Biologia. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Biologia. Rio de Janeiro, RJ. Brasil.
Universidade do Estado do Rio de Janeiro. Departamento de Patologia e Laboratórios. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Biologia. Rio de Janeiro, RJ. Brasil.
Abstract: Twenty specimens of Nectomys squamipes born in captivity, were infected with 500 cercariae by the transcutaneous route. Coprologic examinations were carried out from the 5th to 23rd week after infection. On the 7th, 8th, 12th, 16th, and 23rd weeks the animals were sacrificed and perfused. The oogram was performed in segments of the small intestine (proximal, medial and distal portions) and the large intestine. The average pre-patent period was of 42 days. The average number of eggs varied from 350 on 6th week, to 800 on the 13th. From the 14th week on, the average number of eggs eliminated was lower than 50 per gram of feces. The recovery of worms kept steady on the 7th, 8th, and 12th week (16.85%; 15.45% and 11.95%), decreasing to 7.70% on the 16th week and 8.45% on the 23rd week. The proportion of male/female worms was about the same on the first two weeks, but from the 12th week on, the proportion was: 1,4/1 on the 12th week; 2,5/1 on the 16thweek and 1,8/1 on the 23rd weekThese observations suggest that N. squamipes may used as an experimental model for schistosomiasis mansoni, to wich it develops resistance mechanism, useful for immunity studies.
Keywords: Nectomys squamiques
Schistosoma mansoni
Wild rodents
Experimental model
keywords: Nectomys squamiques
Schistosoma mansoni
Modelo experimental
Roedores selvagens
Issue Date: 1992
Publisher: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
Citation: SOUZA, Valéria Aguiar Mello de et al. Nectomys Squamipes (Rodentia: Cricetidae) as an experimental model for Schistosomiais Mansoni. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 87, Suppl. 1, p. 277-280, 1992.
DOI: 10.1590/S0074-02761992000500052
ISSN: 0074-0276
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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