Please use this identifier to cite or link to this item:
https://www.arca.fiocruz.br/handle/icict/33784
Type
ArticleCopyright
Open access
Collections
- IOC - Artigos de Periódicos [12500]
Metadata
Show full item record
HIV-ASSOCIATED TUBERCULOUS LYMPHADENITIS: THE IMPORTANCE OF POLYMERASE CHAIN REACTION (PCR) AS A COMPLEMENTARY TOOL FOR THE DIAGNOSIS OF TUBERCULOSIS – A STUDY OF 104 PATIENTS
Infecções oportunistas relacionadas com AIDS
Tuberculose
Tuberculose dos linfonodos
Alternative title
Linfadenite tuberculosa associada ao HIV: a importância da reação em cadeia de polimerase (PCR) como ferramenta complementar para o diagnóstico da tuberculose - estudo de 104 pacientesAuthor
Affilliation
Centro Universitário Nilton Lins. Clínica Cirúrgica. Manaus, AM, Brasil.
Fundação de Medicina Tropical do Amazonas. Manaus, AM, Brasil.
Fundação de Medicina Tropical do Amazonas. Manaus, AM, Brasil.
Fundação de Medicina Tropical do Amazonas. Manaus, AM, Brasil.
Centro Universitário Nilton Lins. Clínica Cirúrgica. Manaus, AM, Brasil.
Centro Universitário Nilton Lins. Clínica Cirúrgica. Manaus, AM, Brasil.
Fundação de Medicina Tropical do Amazonas. Manaus, AM, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.
Centro Universitário Nilton Lins. Dermatologia. Manaus, AM, Brasil.
Fundação de Medicina Tropical do Amazonas. Manaus, AM, Brasil.
Fundação de Medicina Tropical do Amazonas. Manaus, AM, Brasil.
Fundação de Medicina Tropical do Amazonas. Manaus, AM, Brasil.
Centro Universitário Nilton Lins. Clínica Cirúrgica. Manaus, AM, Brasil.
Centro Universitário Nilton Lins. Clínica Cirúrgica. Manaus, AM, Brasil.
Fundação de Medicina Tropical do Amazonas. Manaus, AM, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.
Centro Universitário Nilton Lins. Dermatologia. Manaus, AM, Brasil.
Abstract
BACKGROUND: Lymphadenitis is common in HIV-positive patients. Diagnosis of the infections associated with this condition is complex, particularly in the case of tuberculosis. Rapid and specific detection of Mycobacterium tuberculosis (M. tuberculosis) is fundamental in ensuring adequate treatment. In addition, frequent causes of lymphadenitis such as those associated with lymphoma and histoplasmosis, among others, must be eliminated as possible causes. OBJECTIVES: To evaluate the accuracy of polymerase chain reaction as a tool for the diagnosis of lymphadenitis resulting from M. tuberculosis. METHODS: In this study, a protocol was developed using the following procedures: direct microscopy using Ziehl-Neelsen staining, culture in Lowenstein-Jensen medium, histology and polymerase chain reaction. RESULTS: A total of 104 patients were included in the study. According to histopathology, 38 patients (36%) were found to have nonspecific chronic lymphadenitis, 27 (26%) had tuberculous lymphadenitis, 11 patients (10.5%) had lymphoma and 9 (8.7%) had histoplasmosis. When Lowenstein-Jensen culture was performed, positive tests for tuberculous lymphadenitis increased by 30%. With polymerase chain reaction, M. tuberculosis DNA was detected in 6 out of 38 samples of non-specific chronic lymphadenitis. Three of these patients were followed up, developed symptoms of tuberculosis and were cured following specific treatment. CONCLUSION: The data obtained in this study suggest that all cases of lymphadenopathies should be submitted to histopathology, Lowenstein-Jensen or Ogawa culture and polymerase chain reaction. Polymerase chain reaction may prove to be useful in providing an early and accurate detection of cases of extrapulmonary tuberculosis in HIV-positive patients with lymphadenopathies, avoiding empirical treatment and the possible development of resistant strains.
Keywords in Portuguese
HIVInfecções oportunistas relacionadas com AIDS
Tuberculose
Tuberculose dos linfonodos
Share