Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/33841

Type
Article
Copyright
Open access
Collections
Share

Statistics
Metadata
Show full item record

CD4(+)CD25(HIGH) TREG CELLS IN HIV/HTLV CO-INFECTED PATIENTS WITH NEUROPATHY: HIGH EXPRESSION OF ALPHA4 INTEGRIN AND LOWER EXPRESSION OF FOXP3 TRANSCRIPTION FACTOR
Matavele Chissumba, Raquel et al. | Date Issued: 2015
Author
Matavele Chissumba, Raquel
Barbosa, Suse Dayse Silva
Augusto, Ângelo
Maueia, Cremildo
Mabunda, Nédio
Gudo Jr., Eduardo Samo
Bhatt, Nilesh
Jani, Ilesh
Savino, Wilson
Affilliation
Ministry of Health. National Institute of Health. Maputo, Mozambique.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil.
Ministry of Health. National Institute of Health. Maputo, Mozambique.
Ministry of Health. National Institute of Health. Maputo, Mozambique.
Ministry of Health. National Institute of Health. Maputo, Mozambique.
Ministry of Health. National Institute of Health. Maputo, Mozambique.
Ministry of Health. National Institute of Health. Maputo, Mozambique.
Ministry of Health. National Institute of Health. Maputo, Mozambique.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil.
Abstract
Regulatory CD4 T cells (Tregs) are critical in maintaining the homeostasis of the immune system. Quantitative or phenotypic alterations and functional impairment of Tregs have been associated with the development of pathologies including those of the central nervous system. Individuals with HIV-1/HTLV-1 co-infection are more prone to develop neurological complications. The aim of this study was to characterize phenotypically Treg cells in HIV-1/HTLV-1 co-infected Mozambican individuals presenting neurological symptoms.
Keywords in Portuguese
HIV
CD4+CD25High Treg cells
HTLV
Neuropatia
Fator de transcrição Foxp3
 
Keywords
HIV
Neuropathy
CD4 + CD25Células Tregs
HTLV
Foxp3 transcription factor
 
Publisher
BMC
Citation
CHISSUMBA, Raquel Matavele et al. CD4+CD25High Treg cells in HIV/HTLV Co-infected patients with neuropathy: high expression of Alpha4 integrin and lower expression of Foxp3 transcription factor. BMC Immunology, v. 16, n. 52, p. 1-9, 2015.
DOI
10.1186/s12865-015-0116-x
ISSN
1471-2172