| Author | Monteiro, Elizangela Silva | |
| Author | Lorenzato, Luciana Reis | |
| Author | Kenji Nihei, Oscar | |
| Author | Junqueira, Mara | |
| Author | Rabinovich, Gabriel Adrián | |
| Author | Hsu, Daniel Kaiyuan | |
| Author | Liu, Fu-Tong | |
| Author | Savino, Wilson | |
| Author | Chammas, Roger | |
| Author | Villa-Verde, Déa Maria Serra | |
| Access date | 2019-07-04T17:25:40Z | |
| Available date | 2019-07-04T17:25:40Z | |
| Document date | 2007 | |
| Citation | MONTEIRO, Elizangela Silva et al. Altered Expression of Galectin-3 Induces Cortical Thymocyte Depletion and Premature Exit of Immature Thymocytes during Trypanosoma cruzi Infection. The American Journal of Pathology, v. 170, n. 2, p. 546-556, Feb. 2007. | pt_BR |
| ISSN | 0002-9440 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/33853 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Trypanosoma cruzi | pt_BR |
| Subject in Portuguese | Infecção | pt_BR |
| Subject in Portuguese | Galacteina-3 | pt_BR |
| Subject in Portuguese | Depleção timocortical cortical | pt_BR |
| Subject in Portuguese | Timócitos imaturos | pt_BR |
| Subject in Portuguese | Atrofia do Timo | pt_BR |
| Title | Altered expression of galectin-3 induces cortical thymocyte depletion and premature exit of immature thymocytes during Trypanosoma cruzi infection | pt_BR |
| Type | Article | |
| DOI | 10.2353/ajpath.2007.060389 | |
| Abstract | During acute infection with Trypanosoma cruzi, the causative agent of Chagas' disease, the thymus undergoes intense atrophy followed by a premature escape of CD4+CD8+ immature cortical thymocytes. Here we report a pivotal role for the endogenous lectin galectin-3 in accelerating death of thymocytes and migration of these cells away from the thymus after T. cruzi infection. We observed a pronounced increase in galectin-3 expression that paralleled the extensive depletion of CD4+CD8+ immature thymocytes after infection. In vitro, recombinant galectin-3 induced increased levels of death in cortical immature thymocytes. Consistent with the role of galectin-3 in promoting cell death, thymuses from gal-3-/- mice did not show cortical thymocyte depletion after parasite infection in vivo. In addition, galectin-3 accelerated laminin-driven CD4+CD8+ thymocyte migration in vitro and in vivo induced exportation of CD4+CD8+ cells from the thymus to the peripheral compartment. Our findings provide evidence of a novel role for galectin-3 in the regulation of thymus physiology and identify a potential mechanism based on protein-glycan interactions in thymic atrophy associated with acute T. cruzi infection. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina. Laboratório de Oncologia Experimental. São Paulo, SP, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade de Buenos Aires. Faculdade de Medicina. Hospital de Clínicas José de San Martin. Divisão de Imunogenética. Buenos Ires, Argentina. | pt_BR |
| Affilliation | University of California. Department of Dermatology. Los Angeles, CA, USA. | pt_BR |
| Affilliation | University of California. Department of Dermatology. Los Angeles, CA, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina. Laboratório de Oncologia Experimental. São Paulo, SP, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | Trypanosoma cruzi | pt_BR |
| Subject | Infection | pt_BR |
| Subject | Galectin-3 | pt_BR |
| Subject | Cortical Thymocyte Depletion | pt_BR |
| Subject | Thymic atrophy | pt_BR |
| Subject | Immature Thymocytes | pt_BR |
| Embargo date | 2022-01-01 | |
