| Author | Cardoso, M. A. | |
| Author | Brasil, P. E. A. A. do | |
| Author | Schmaltz, C. A. S. | |
| Author | Sant'Anna, F. M. | |
| Author | Rolla, V. C. | |
| Access date | 2019-07-15T14:07:38Z | |
| Available date | 2019-07-15T14:07:38Z | |
| Document date | 2017 | |
| Citation | CARDOSO, Mayara A. et al. Tuberculosis treatment outcomes and factors associated with each of them in a cohort followed up between 2010 and 2014. Biomed Research International, v. 2017, p. 1-7, 2017. | pt_BR |
| ISSN | 2314-6133 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/34083 | |
| Language | eng | pt_BR |
| Publisher | Hindawi | pt_BR |
| Rights | open access | pt_BR |
| Title | Tuberculosis treatment outcomes and factors associated with each of them in a cohort followed up between 2010 and 2014 | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1155/2017/3974651 | |
| Abstract | Tuberculosis treatment has undergone recent changes in Brazil. Objective: To assess whether favorable outcomes on tuberculosis therapy improved in recent years. Methods: Retrospective observational study, based on primary data of tuberculosis patients, followed at INI-FIOCRUZ, from January 2012 to December 2014. Results: The outcomes observed were as follows: cure (80%), default (14%), treatment failure (5%), and death (1%). HIV infection without antiretroviral therapy [OR 0.34 (0.15–0.79)], tuberculosis diagnosis based on sputum smear [OR 0.22 (0.07–0.74)], drug use [OR 0.22 (0.11–0.46)], and/or treatment interruption due to adverse reactions [OR 0.23 (0.08–0.67)] decreased the chance of cure. Predictors of default, that is, use of noninjecting drugs [OR 3.00 (95% CL 1.31–6.88)], treatment interruption due to adverse reactions [OR 6.30 (1.81–21.95)], low schooling [OR 2.59 (2.15–5.82)], higher age [OR 0.44 (0.23–0.82)], and female gender [OR 0.28 (0.11–0.71)], reduced the chance of treatment default. Tuberculosis diagnosis based on sputum smear [OR 7.77 (1.94–31.09)] and/or arterial hypertension [OR 4.07 (1.25–13.18)] was associated with treatment failure. Conclusion: Mortality and default were low considering the prevalence of HIV infection; however cure was not significantly increased. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Programa de Pós-graduação em Pesquisa Clínica em Doenças Infecciosas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa em Imunização e Vigilância em Saúde. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobacterioses. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobacterioses. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Tuberculosis | pt_BR |
| Subject | Treatment | pt_BR |
| Subject | Brazil | pt_BR |
| e-ISSN | 2314-6141 | |
