Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/34083
Title: Tuberculosis treatment outcomes and factors associated with each of them in a cohort followed up between 2010 and 2014
Authors: Cardoso, M. A.
Brasil, P. E. A. A. do
 Schmaltz, C. A. S.
Sant'Anna, F. M.
Rolla, V. C.
Affilliation: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Programa de Pós-graduação em Pesquisa Clínica em Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa em Imunização e Vigilância em Saúde. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobacterioses. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobacterioses. Rio de Janeiro, RJ, Brasil.
Abstract: Tuberculosis treatment has undergone recent changes in Brazil. Objective: To assess whether favorable outcomes on tuberculosis therapy improved in recent years. Methods: Retrospective observational study, based on primary data of tuberculosis patients, followed at INI-FIOCRUZ, from January 2012 to December 2014. Results: The outcomes observed were as follows: cure (80%), default (14%), treatment failure (5%), and death (1%). HIV infection without antiretroviral therapy [OR 0.34 (0.15–0.79)], tuberculosis diagnosis based on sputum smear [OR 0.22 (0.07–0.74)], drug use [OR 0.22 (0.11–0.46)], and/or treatment interruption due to adverse reactions [OR 0.23 (0.08–0.67)] decreased the chance of cure. Predictors of default, that is, use of noninjecting drugs [OR 3.00 (95% CL 1.31–6.88)], treatment interruption due to adverse reactions [OR 6.30 (1.81–21.95)], low schooling [OR 2.59 (2.15–5.82)], higher age [OR 0.44 (0.23–0.82)], and female gender [OR 0.28 (0.11–0.71)], reduced the chance of treatment default. Tuberculosis diagnosis based on sputum smear [OR 7.77 (1.94–31.09)] and/or arterial hypertension [OR 4.07 (1.25–13.18)] was associated with treatment failure. Conclusion: Mortality and default were low considering the prevalence of HIV infection; however cure was not significantly increased.
Keywords: Tuberculosis
Treatment
Brazil
Issue Date: 2017
Publisher: Hindawi
Citation: CARDOSO, Mayara A. et al. Tuberculosis treatment outcomes and factors associated with each of them in a cohort followed up between 2010 and 2014. Biomed Research International, v. 2017, p. 1-7, 2017.
DOI: 10.1155/2017/3974651
ISSN: 2314-6133
Copyright: open access
Appears in Collections:INI - Artigos de Periódicos

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