Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/34113
Title: Influenza epidemiology and influenza vaccine effectiveness during the 2015-2016 season: results from the Global Influenza Hospital Surveillance Network
Authors: Puig-Barberà, Joan
Mira-Iglesias, Ainara
Burtseva, Elena
Cowling, Benjamin J.
Serhat, Unal
Ruiz-Palacios, Guillermo Miguel
Launay, Odile
Kyncl, Jan
Koul, Parvaiz
Siqueira, Marilda M.
Sominina, Anna
Global Influenza Hospital Surveillance Network
Affilliation: Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana. FISABIO, Valencia, Spain.
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana. FISABIO, Valencia, Spain.
Ivanovsky Institute of Virology FSBI “N.F. Gamaleya NRCEM” Ministry of Health. Moscow, Russian Federation.
School of Public Health. Li Ka Shing Faculty of Medicine. Hong Kong. Hong Kong, Special Administrative Region of China.
Turkish Society of Internal Medicine. Ankara, Turkey.
Salvador Zubirán National Institute of Medical Sciences and Nutrition. Vasco de Quiroga 15, Belisario Domínguez Sección 16, 14080 Tlalpan, CDMX, Mexico.
INSERM, F-CRIN,Réseau National d’Investigation Clinique en Vaccinologie (I-REIVAC), CIC Cochin Pasteur. Paris, France / Université Paris Descartes, Sorbonne Paris Cité and Assistance Publique Hôpitaux de Paris. Hôpital Cochin. Paris, France.
National Institute of Public Health. Prague, Czech Republic.
Department of Internal and Pulmonary Medicine. Sher-i-Kashmir Institute of Medical Sciences (SKIMS). Soura, Bemina, Srinagar, Jammu & Kashmir 190011, India.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Research Institute of Influenza. WHO National Influenza Centre of Russia / Ministry of Healthcare of the Russian Federation. St. Petersburg, Russian Federation.
Abstract: Background: The Global Influenza Hospital Surveillance Network is an international platform whose primary objective is to study severe cases of influenza requiring hospitalization. Methods: During the 2015–2016 influenza season, 11 sites in the Global Influenza Hospital Surveillance Network in nine countries (Russian Federation, Czech Republic, Turkey, France, China, Spain, Mexico, India, and Brazil) participated in a prospective, active-surveillance, hospital-based epidemiological study. Influenza infection was confirmed by reverse transcription-polymerase chain reaction. Influenza vaccine effectiveness (IVE) against laboratory-confirmed influenza was estimated using a test-negative approach. Results: 9882 patients with laboratory results were included of which 2415 (24.4%) were positive for influenza, including 1415 (14.3%) for A(H1N1)pdm09, 235 (2.4%) for A(H3N2), 180 (1.8%) for A not subtyped, 45 (0.5%) for B/Yamagata-lineage, 532 (5.4%) for B/Victoria-lineage, and 33 (0.3%) for B not subtyped. Of included admissions, 39% were < 5 years of age and 67% had no underlying conditions. The odds of being admitted with influenza were higher among pregnant than nonpregnant women (odds ratio, 2.82 [95% confidence interval (CI), 1.90 to 4.19]). Adjusted IVE against influenza-related hospitalization was 16.3% (95% CI, 0.4 to 29.7). Among patients targeted for influenza vaccination, adjusted IVE against hospital admission with influenza was 16.2% (95% CI, − 3.6 to 32.2) overall, 23.0% (95% CI, − 3.3 to 42.6) against A(H1N1) pdm09, and − 25.6% (95% CI, − 86.3 to 15.4) against B/Victoria lineage. Conclusions: The 2015–2016 influenza season was dominated by A(H1N1)pdm09 and B/Victoria-lineage. Hospitalization with influenza often occurred in healthy and young individuals, and pregnant women were at increased risk of influenzarelated hospitalization. Influenza vaccines provided low to moderate protection against hospitalization with influenza and no protection against the predominant circulating B lineage, highlighting the need for more effective and broader influenza vaccines.
Keywords: Influenza Virus
Surveillance
Vaccine
Hospitalization
Epidemiological study
keywords: Vírus Influenza
Vigilância
Hospitalização
Estudo epidemiológico
Vacina
Issue Date: 2019
Publisher: BMC
Citation: BARBERÀ, Joan Puig et al. Influenza epidemiology and influenza vaccine effectiveness during the 2015–2016 season: results from the Global Influenza Hospital Surveillance Network. BMC Infectious Diseases, v. 19, n. 415, p. 1-22, May 2019.
DOI: 10.1186/s12879-019-4017-0
ISSN: 1471-2334
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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