| Author | Farias, Leonardo Paiva | |
| Author | Chalmers, Iain W. | |
| Author | Perally, Samirah | |
| Author | Rofatto, Henrique K. | |
| Author | Jackson, Colin J. | |
| Author | Brown, Martha | |
| Author | Khouri, Mariana I. | |
| Author | Barbosa, Mayra M. F. | |
| Author | Hensbergen, Paul J. | |
| Author | Hokke, Cornelis H. | |
| Author | Leite, Luciana C. C. | |
| Author | Hoffmann, Karl F. | |
| Access date | 2019-07-15T18:39:31Z | |
| Available date | 2019-07-15T18:39:31Z | |
| Document date | 2019 | |
| Citation | FARIAS, Leonardo Paiva et. al. Schistosoma mansoni venom allergen-like proteins: phylogenetic relationships, stage-specific transcription and tissue localization as predictors of immunological cross-reactivity. International Journal for Parasitology, v. 49, p. 593–599, 2019. | pt_BR |
| ISSN | 0020-7519 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/34114 | |
| Description | O artigo encontra-se disponível para download no site do Editor. | pt_BR |
| Sponsorship | Welcome Trust
(UK) (WT084273/Z/07/Z) to KFH, Fundação Butantan, Fundação
de Amparo à Pesquisa do Estado de São Paulo (Brazil) to LPF and
LLC (2012/23124-4), Conselho Nacional de Desenvolvimento
Científico e Tecnológico (CNPq) to LCCL and Coordenação de Aperfeiçoamento
de Pessoal de Nível Superior – Brasil (CAPES) –
Finance Code 001, and by fellowships from Fundação de Amparo
à Pesquisa do Estado de São Paulo (FAPESP, Brazil) to LPF
(2008/57946-5) and HKF (2007/07685-8) and from CNPq to MIK
(160861/2017-9). We thank Dra. Eliana Nakano and Ms. Patricia
A. Miyasato for supplying the parasite stages and to Alexsander
Seixas de Souza for confocal microscopy (FAPESP 00/11624-5)
imaging support, all from Instituto Butantan, Brazil. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Veneno alérgeno-like | pt_BR |
| Subject in Portuguese | Reatividade cruzada imunológica | pt_BR |
| Subject in Portuguese | Localização de tecido | pt_BR |
| Subject in Portuguese | Schistosoma mansoni | pt_BR |
| Title | Schistosoma mansoni venom allergen-like proteins: phylogenetic relationships, stage-specific transcription and tissue localization as predictors of immunological cross-reactivity | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1016/j.ijpara.2019.03.003 | |
| Abstract | Schistosoma mansoni venom allergen-like proteins (SmVALs) are part of a diverse protein superfamily partitioned into two groups (group 1 and group 2). Phylogenetic analyses of group 1 SmVALs revealed that members could be segregated into subclades (A-D); these subclades share similar gene expression patterns across the parasite lifecycle and immunological cross-reactivity. Furthermore, whole-mount in situ hybridization demonstrated that the phylogenetically, transcriptionally and immunologically-related SmVAL4, 10, 18 and 19 (subclade C) were all localized to the pre-acetabular glands of immature cercariae. Our results suggest that SmVAL group 1 phylogenetic relationships, stage-specific transcriptional profiles and tissue localization are predictive of immunological cross-reactivity. | pt_BR |
| Affilliation | Instituto Butantan. Centro de Biotecnologia. São Paulo, SP, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Aberystwyth University. Institute of Biological. Environmental and Rural Sciences. Aberystwyth, UK. | pt_BR |
| Affilliation | Aberystwyth University. Institute of Biological. Environmental and Rural Sciences. Aberystwyth, UK. | pt_BR |
| Affilliation | Instituto Butantan. Centro de Biotecnologia. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Aberystwyth University. Institute of Biological. Environmental and Rural Sciences. Aberystwyth, UK. | pt_BR |
| Affilliation | Aberystwyth University. Institute of Biological. Environmental and Rural Sciences. Aberystwyth, UK. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Instituto Butantan. Centro de Biotecnologia. São Paulo, SP, Brasil / Universidade de São Paulo. Pós-Graduação Interunidades em Biotecnologia. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Leiden University Medical Centre. Center for Proteomics and Metabolomics. RC Leiden, The Netherlands. | pt_BR |
| Affilliation | Leiden University Medical Centre. Department of Parasitology. RC Leiden, The Netherlands. | pt_BR |
| Affilliation | Instituto Butantan. Centro de Biotecnologia. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Aberystwyth University. Institute of Biological. Environmental and Rural Sciences. Aberystwyth, UK. | pt_BR |
| Subject | Venom allergen-like | pt_BR |
| Subject | Immunological cross reactivity | pt_BR |
| Subject | Tissue localization | pt_BR |
| Subject | Schistosoma mansoni | pt_BR |
