Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/34114
Title: Schistosoma mansoni venom allergen-like proteins: phylogenetic relationships, stage-specific transcription and tissue localization as predictors of immunological cross-reactivity
Authors: Farias, Leonardo Paiva
Chalmers, Iain W.
Perally, Samirah
Rofatto, Henrique K.
Jackson, Colin J.
Brown, Martha
Khouri, Mariana I.
Barbosa, Mayra M. F.
Hensbergen, Paul J.
Hokke, Cornelis H.
Leite, Luciana C. C.
Hoffmann, Karl F.
Affilliation: Instituto Butantan. Centro de Biotecnologia. São Paulo, SP, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
Aberystwyth University. Institute of Biological. Environmental and Rural Sciences. Aberystwyth, UK.
Aberystwyth University. Institute of Biological. Environmental and Rural Sciences. Aberystwyth, UK.
Instituto Butantan. Centro de Biotecnologia. São Paulo, SP, Brasil.
Aberystwyth University. Institute of Biological. Environmental and Rural Sciences. Aberystwyth, UK.
Aberystwyth University. Institute of Biological. Environmental and Rural Sciences. Aberystwyth, UK.
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
Instituto Butantan. Centro de Biotecnologia. São Paulo, SP, Brasil / Universidade de São Paulo. Pós-Graduação Interunidades em Biotecnologia. São Paulo, SP, Brasil.
Leiden University Medical Centre. Center for Proteomics and Metabolomics. RC Leiden, The Netherlands.
Leiden University Medical Centre. Department of Parasitology. RC Leiden, The Netherlands.
Instituto Butantan. Centro de Biotecnologia. São Paulo, SP, Brasil.
Aberystwyth University. Institute of Biological. Environmental and Rural Sciences. Aberystwyth, UK.
Abstract: Schistosoma mansoni venom allergen-like proteins (SmVALs) are part of a diverse protein superfamily partitioned into two groups (group 1 and group 2). Phylogenetic analyses of group 1 SmVALs revealed that members could be segregated into subclades (A-D); these subclades share similar gene expression patterns across the parasite lifecycle and immunological cross-reactivity. Furthermore, whole-mount in situ hybridization demonstrated that the phylogenetically, transcriptionally and immunologically-related SmVAL4, 10, 18 and 19 (subclade C) were all localized to the pre-acetabular glands of immature cercariae. Our results suggest that SmVAL group 1 phylogenetic relationships, stage-specific transcriptional profiles and tissue localization are predictive of immunological cross-reactivity.
Keywords: Venom allergen-like
Immunological cross reactivity
Tissue localization
Schistosoma mansoni
keywords: Veneno alérgeno-like
Reatividade cruzada imunológica
Localização de tecido
Schistosoma mansoni
Issue Date: 2019
Publisher: Elsevier
Citation: FARIAS, Leonardo Paiva et. al. Schistosoma mansoni venom allergen-like proteins: phylogenetic relationships, stage-specific transcription and tissue localization as predictors of immunological cross-reactivity. International Journal for Parasitology, v. 49, p. 593–599, 2019.
Description: O artigo encontra-se disponível para download no site do Editor.
DOI: 10.1016/j.ijpara.2019.03.003
ISSN: 0020-7519
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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