Please use this identifier to cite or link to this item:
https://www.arca.fiocruz.br/handle/icict/34128
Type
ArticleCopyright
Restricted access
Embargo date
2025-01-01
Collections
- IOC - Artigos de Periódicos [12659]
Metadata
Show full item record
RESPIRATORY TRACT VIRAL INFECTIONS IN BONE MARROW TRANSPLANT PATIENTS
Author
Affilliation
Universidade Federal do Paraná. Hospital de Clínicas. Laboratório de Virologia. Curitiba, PR, Brasil.
Universidade Federal do Paraná. Hospital de Clínicas. Laboratório de Virologia. Curitiba, PR, Brasil.
Universidade Federal do Paraná. Hospital de Clínicas. Laboratório de Virologia. Curitiba, PR, Brasil.
Universidade Federal do Paraná. Hospital de Clínicas. Laboratório de Virologia. Curitiba, PR, Brasil.
Universidade Federal do Paraná. Hospital de Clínicas. Laboratório de Virologia. Curitiba, PR, Brasil.
Universidade Federal do Paraná. Hospital de Clínicas. Serviço de Transplante de Medula Óssea. Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ. Brasil.
Universidade Federal do Paraná. Hospital de Clínicas. Laboratório de Virologia. Curitiba, PR, Brasil.
Universidade Federal do Paraná. Hospital de Clínicas. Laboratório de Virologia. Curitiba, PR, Brasil.
Universidade Federal do Paraná. Hospital de Clínicas. Laboratório de Virologia. Curitiba, PR, Brasil.
Universidade Federal do Paraná. Hospital de Clínicas. Laboratório de Virologia. Curitiba, PR, Brasil.
Universidade Federal do Paraná. Hospital de Clínicas. Serviço de Transplante de Medula Óssea. Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ. Brasil.
Abstract
Background. Community respiratory viruses such as respiratory syncytial virus (RSV), adenovirus, influenza A, influenza B, and the parainfluenza group are frequent causes of respiratory disease in bone marrow
transplant (BMT) patients. Material and Methods. During the period from
March 1993 to August 1999, 810 samples of respiratory secretions, nasopharyngeal aspirate (NPA) or bronchoalveolar lavage (BAL), from 722 patients with upper respiratory infections symptoms at the BMT unit
of the Federal University in the state of Paran´ a, Brazil were evaluated for respiratory virus infection. Results. One hundred thirty-six (17%) samples were reactive in 62 patients. RSV was found in 30 of 62 (48%), influenza A in 14 of 62 (23%), influenza B in 9 of 62 (15%), parainfluenza group in 7 of 62 (11%), and adenovirus in 2 of 62 (3%) infected patients. The most
frequent clinical manifestations were cough and fever. Pneumonia occurred in 19 of 62 (31%) cases. The mortality rate was 23 of 62 (37%), being higher among patients infected with adenovirus and influenza A. Conclusions. Infections in BMT patients occurred during the outbreak period of these viruses in the community, highlighting the need to establish surveillance
measures in units with immunocompromised patients in addition to the development of sensitive and rapid diagnostic tests for the detection of these viruses in patients with respiratory symptoms.
Share