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HIGH LEVEL OF PD-1 EXPRESSION ON HEPATITIS C VIRUS (HCV)-SPECIFIC CD8+ AND CD4+ T CELLS DURING ACUTE HCV INFECTION, IRRESPECTIVE OF CLINICAL OUTCOME
Kasprowicz, Victoria et al. | Date Issued: 2008
Author
Kasprowicz, Victoria
Schulze Zur Wiesch, Julian
Kuntzen, Thomas
Nolan, Brian E.
Longworth, Steven
Berical, Andrew
Blum, Jenna
McMahon, Cory
Reyor, Laura L.
Elias, Nahel
Kwok, William W.
McGovern, Barbara G.
Freeman, Gordon
Chung, Raymond T.
Klenerman, Paul
Lewis-Ximenez, Lia
Walker, Bruce D.
Allen, Todd M.
Kim, Arthur Y.
Lauer, Georg M.
Affilliation
Partners AIDS Research Center. Massachusetts General Hospital. Harvard Medical School. Charlestown, Massachussets, USA.
Partners AIDS Research Center. Massachusetts General Hospital. Harvard Medical School. Charlestown, Massachussets, USA / Med. Klinik I, Universitát Hamburg. Germany / Howard Hughes Medical Institute. Chevy Chase, Maryland, USA.
Partners AIDS Research Center. Massachusetts General Hospital. Harvard Medical School. Charlestown, Massachussets, USA.
Partners AIDS Research Center. Massachusetts General Hospital. Harvard Medical School. Charlestown, Massachussets, USA.
Partners AIDS Research Center. Massachusetts General Hospital. Harvard Medical School. Charlestown, Massachussets, USA.
Partners AIDS Research Center. Massachusetts General Hospital. Harvard Medical School. Charlestown, Massachussets, USA.
Partners AIDS Research Center. Massachusetts General Hospital. Harvard Medical School. Charlestown, Massachussets, USA.
Partners AIDS Research Center. Massachusetts General Hospital. Harvard Medical School. Charlestown, Massachussets, USA.
Partners AIDS Research Center. Massachusetts General Hospital. Harvard Medical School. Charlestown, Massachussets, USA.
Partners AIDS Research Center. Massachusetts General Hospital. Harvard Medical School. Charlestown, Massachussets, USA / Transplantation Unit, Department of Surgery, Massachusetts General Hospital. Boston, Massachusetts. USA.
Benaroya Research Institute at Virginia Mason. Seattle, Washington, USA.
Lemuel Shattuck Hospital. Tufts University School of Medicine. Boston, Massachusetts, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute / Department of Medicine, Harvard Medical School. Boston, Massachusetts, USA.
Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital. Boston, Massachusetts, USA / Howard Hughes Medical Institute. Chevy Chase, Maryland, USA.
Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, University of Oxford. Oxford, United Kingdom.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.
Partners AIDS Research Center. Massachusetts General Hospital. Harvard Medical School. Charlestown, Massachussets, USA / Howard Hughes Medical Institute. Chevy Chase, Maryland, USA.
Partners AIDS Research Center. Massachusetts General Hospital. Harvard Medical School. Charlestown, Massachussets, USA.
Partners AIDS Research Center. Massachusetts General Hospital. Harvard Medical School. Charlestown, Massachussets, USA.
Partners AIDS Research Center. Massachusetts General Hospital. Harvard Medical School. Charlestown, Massachussets, USA.
Abstract
We monitored expression of PD-1 (a mediator of T-cell exhaustion and viral persistence) on hepatitis C virus (HCV)-specific CD8(+) and CD4(+) T cells from blood and liver during acute and chronic infections and after the resolved infection stage. PD-1 expression on HCV-specific T cells was high early in acute infection irrespective of clinical outcome, and most cells continued to express PD-1 in resolved and chronic stages of infection; intrahepatic expression levels were especially high. Our results suggest that an analysis of PD-1 expression alone is not sufficient to predict infection outcome or to determine T-cell functionality in HCV infection.
Keywords in Portuguese
Vírus da hepatite C
Infecção aguda
Células CD8
Cédulas CD4
Células T
Expressão de PD-1
 
Keywords
Hepatitis C virus
Acute HCV Infection
PD-1 Expression
T cells
CD8
CD4
 
Publisher
American Society for Microbiology
Citation
KASPROWICZ, Victoria et al. High Level of PD-1 Expression on Hepatitis C Virus (HCV)-Specific CD8 and CD4 T Cells during Acute HCV Infection, Irrespective of Clinical Outcome. Journal of Virology, v. 82, n. 6, p. 3154-3160, Mar. 2008.
DOI
10.1128/JVI.02474-07
ISSN
0022-538X
Notes
AUTHOR’S CORRECTION High Level of PD-1 Expression on Hepatitis C Virus (HCV)-Specific CD8 and CD4 T Cells during Acute HCV Infection, Irrespective of Clinical Outcome Victoria Kasprowicz, Julian Schulze zur Wiesch, Thomas Kuntzen, Brian E. Nolan, Steven Longworth, Andrew Berical, Jenna Blum, Cory McMahon, Laura L. Reyor, Nahel Elias, William W. Kwok, Barbara G. McGovern, Gordon Freeman, Raymond T. Chung, Paul Klenerman, Lia Lewis-Ximenez, Bruce D. Walker, Todd M. Allen, Arthur Y. Kim, and Georg M. Lauer Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, 6th Floor, Room 6001, Charlestown, Massachusetts 02129-2000; Med. Klinik I, Universita¨t Hamburg, Germany; Transplantation Unit, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts 02114; Benaroya Research Institute at Virginia Mason, Seattle, Washington; Lemuel Shattuck Hospital and Tufts University School of Medicine, Boston, Massachusetts; Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115; Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114; Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, South Parks Road, Oxford OX1 3SY, United Kingdom; Departmento de Virologia, Instituto Oswaldo Cruz/Fiocruz, Rio de Janeiro, Brazil; and Howard