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GLOMERULOID HEMANGIOMA AS A LATE MANIFESTATION OF POEMS SYNDROME
Amorim, G. Moreira et al. | Data do documento: 2018
Autor(es)
Amorim, G. Moreira
Sodré, C.
Falcão, E. Mastrangelo Marinho
Cuzzi, T.
Fernandes, R. Timbó
Ramos-e-Silva, M.
Afiliação
Federal University of Rio de Janeiro. School of Medicine. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. University Hospital. Rio de Janeiro, RJ, Brazil.
Federal University of Rio de Janeiro. School of Medicine. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. University Hospital. Rio de Janeiro, RJ, Brazil.
Federal University of Rio de Janeiro. School of Medicine. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. University Hospital. Rio de Janeiro, RJ, Brazil.
Federal University of Rio de Janeiro. School of Medicine. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. University Hospital. Rio de Janeiro, RJ, Brazil.
Federal University of Rio de Janeiro. School of Medicine. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. University Hospital. Rio de Janeiro, RJ, Brazil.
Federal University of Rio de Janeiro. School of Medicine. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. University Hospital. Rio de Janeiro, RJ, Brazil.
Resumo em Inglês
Glomeruloid hemangiomas were first described by Chan in 1990 as a cutaneous marker of POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal proteinemia, and Skin changes). POEMS syndrome is a multisystem disease with a significant cutaneous involvement. Among its manifestations, hemangiomas are common, observed in up to one third of the patients, and, although specific, the glomeruloid subtype is very rare. The vascular endothelium growth factor (VEGF) is an angiogenic stimulation factor, which also induces increased systemic vascular permeability. Thus, a scenario of overexpression of VEGF can credibly lead to the assumption of an association between cutaneous hemangiomas and systemic manifestations, implying prognostic and therapeutic considerations and reinforcing the importance of dermatological periodical consultations for these patients. We report the case of a patient in whom glomeruloid hemangiomas marked the recurrence of POEMS syndrome, occurring before the systemic symptoms.
Palavras-chave em inglês
POEMS syndrome
Glomeruloid hemangioma
Vascular endothelium growth factor
VEGF
 
Editor
Croatian Medical Association
Referência
AMORIM, Gustavo Moreira et al. Glomeruloid hemangioma as a late manifestation of POEMS syndrome. Acta Dermatovenerologica Croatica, v. 26, n. 4, p. 321-324, 2018.
DOI
10.1111/j.1365-2230.2008.02997.x
ISSN
1330-027X
Notas
Tullia Cuzzi. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.