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2020-07-22
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18F-FLUORO-2-DEOXYGLUCOSE PET INFORMS NEUTROPHIL ACCUMULATION AND ACTIVATION IN LIPOPOLYSACCHARIDE-INDUCED ACUTE LUNG INJURY
Rodrigues, Rosana S. et al. | Date Issued: 2017
Author
Rodrigues, Rosana S.
Bozza, Fernando A.
Hanrahan, Christopher J.
Wang, Li-Ming
Wu, Qi
Hoffman, John M.
Zimmerman, Guy A.
Morton, Kathryn A.
Affilliation
Federal University of Rio de Janeiro. Department of Radiology. Rio de Janeiro, RJ, Brazil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
University of Utah. School of Medicine. Department of Radiology and Imaging Sciences. Salt Lake City, UT, USA.
University of Utah. School of Medicine. Department of Radiology and Imaging Sciences. Salt Lake City, UT, USA.
University of Utah. School of Medicine. Department of Radiology and Imaging Sciences. Salt Lake City, UT, USA.
University of Utah. School of Medicine. Department of Internal Medicine. Salt Lake City, UT, USA.
University of Utah. School of Medicine. Department of Radiology and Imaging Sciences. Salt Lake City, UT, USA.
Abstract
Molecular imaging of the earliest events related to the development of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) could facilitate therapeutic development and patient management. We previously reported that 18F-fluoro-2-deoxyglucose (18F-FDG) PET identifies ALI/ARDS prior to radiographic abnormalities. The purpose of this study was to establish the time courses of 18F-FDG uptake, edema and neutrophil recruitment in an endotoxin-induced acute lung injury model and to examine molecular events required for 14C-2DG uptake in activated neutrophils.
Keywords
18F-fluordeoxyglucose
FDG
Neutrophils
ARDS
Lipopolysaccharide
Acute lung injury
Platelet activating factor
 
Publisher
Sociedade Brasileira de Dermatologia
Citation
RODRIGUES, Rosana S. et al. 8F-Fluoro-2-deoxyglucose PET informs neutrophil accumulation and activation in lipopolysaccharide-induced acute lung injury. Nuclear Medicine and Biology, v. 48, p. 52-62, May 2017.
DOI
10.1016/j.nucmedbio.2017.01.005
ISSN
0969-8051