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2030-12-31
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- INI - Artigos de Periódicos [3467]
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SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF A PHENANTHROLINE-ISONIAZID HYBRID LIGAND AND ITS AG+ AND MN2+ COMPLEXES
Metal complexes
Antibacterial activity
Antibiotic resistance
Anti-tuberculosis activity
Author
Affilliation
Maynooth University. Department of Chemistry. Maynooth, County Kildare, Ireland.
Maynooth University. Department of Chemistry. Maynooth, County Kildare, Ireland.
Maynooth University. Department of Chemistry. Maynooth, County Kildare, Ireland.
Technological University Dublin. Focas Research Institute. The Inorganic Pharmaceutical and Biomimetic Research Centre. Dublin, Ireland.
University of Dublin. School of Chemistry Trinity College Dublin. Dublin, Ireland.
Federal University of Rio de Janeiro. Microbiology Institute Paulo de Góes. Department of General Microbiology. Rio de Janeiro, RJ, Brazil.
Federal University of Rio de Janeiro. Microbiology Institute Paulo de Góes. Department of General Microbiology. Rio de Janeiro, RJ, Brazil.
Federal University of Rio de Janeiro. Microbiology Institute Paulo de Góes. Department of General Microbiology. Rio de Janeiro, RJ, Brazil.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Bacteriologia e Bioensaios. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Bacteriologia e Bioensaios. Rio de Janeiro, RJ, Brasil.
Federal University of Rio de Janeiro. Microbiology Institute Paulo de Góes. Department of General Microbiology. Rio de Janeiro, RJ, Brazil.
Maynooth University. Department of Chemistry. Maynooth, County Kildare, Ireland.
Maynooth University. Department of Chemistry. Maynooth, County Kildare, Ireland.
Technological University Dublin. Focas Research Institute. The Inorganic Pharmaceutical and Biomimetic Research Centre. Dublin, Ireland.
University of Dublin. School of Chemistry Trinity College Dublin. Dublin, Ireland.
Federal University of Rio de Janeiro. Microbiology Institute Paulo de Góes. Department of General Microbiology. Rio de Janeiro, RJ, Brazil.
Federal University of Rio de Janeiro. Microbiology Institute Paulo de Góes. Department of General Microbiology. Rio de Janeiro, RJ, Brazil.
Federal University of Rio de Janeiro. Microbiology Institute Paulo de Góes. Department of General Microbiology. Rio de Janeiro, RJ, Brazil.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Bacteriologia e Bioensaios. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Bacteriologia e Bioensaios. Rio de Janeiro, RJ, Brasil.
Federal University of Rio de Janeiro. Microbiology Institute Paulo de Góes. Department of General Microbiology. Rio de Janeiro, RJ, Brazil.
Abstract
Hydrazide ligand, (Z)-N'-(6-oxo-1,10-phenanthrolin-5(6H)-ylidene)isonicotinohydrazide, 1 forms from a 1:1 Schiff base condensation reaction between isoniazid (INH) and 1,10-phenanthroline-5,6-dione (phendione). Ag+ and Mn2+ complexes with 1:2 metal:ligand stoichiometry are prepared: [Ag(1)2]NO3, [Ag(1)2]BF4 and [Mn(1)2](NO3)2. Polymeric {[Ag(1)(NO3)]}n has 1:1 stoichiometry and forms upon infusion of CH2Cl2 into a DMSO solution of [Ag(1)2]NO3. {[Ag(1)(NO3)]}n was structurally characterized using X-ray crystallography. Metal-free 1 and its 1:2 complexes exhibit very good, broad-spectrum antimicrobial activity and are not excessively toxic to mammalian cells (A549 lineage).
Keywords
PhenanthrolinesMetal complexes
Antibacterial activity
Antibiotic resistance
Anti-tuberculosis activity
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