Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/34779
Title: Assessment of Genetic Diversity of HTLV-1 ORF-I Sequences Collected from Patients with Different Clinical Profiles
Authors: Borba, Melina Mosquera Navarro
Farre, Maria de Lourdes
Bittencourt, Achilea Lisboa
Amarante, Maria Fernanda de Castro
Castro Filho, Bernardo Galvão
Santos, Luciane Amorim
Araújo, Thessika Hialla Almeida
Alcantara, Luiz Carlos Junior
Barreto, Fernanda Khouri
Affilliation: Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Catalan Institute of Oncology. Bellvitge Biomedical Research Institute. Barcelona, Spain.
Universidade Federal da Bahia. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto Multidisciplinar em Saúde. Vitória da Conquista, BA, Brasil.
Abstract: The human T cell lymphotropic virus type 1 (HTLV-1) infects 5 to 10 million individuals and remains without specific treatment. This retrovirus genome is composed of the genes gag, pol, env, and a region known as pX. This region contains four open reading frames (ORFs) that encode specific proteins. The ORF-I produces the protein p12 and its cleavage product, p8. In this study, we analyzed the genetic diversity of 32 ORF-I sequences from patients with different clinical profiles. Seven amino acid changes with frequency over 5% were identified: G29S, P34L, L55F, F61L, S63P, F78L, and S91P. The identification of regions where the posttranslational sites were identified showed a high identity among the sequences and the amino acid changes exclusive of specific clinical profile were found in less than 5% of the samples. We compare the findings with 2.406 sequences available in GenBank. The low overall genetic diversity found suggested that this region could be used in the HTLV-1 vaccine development.
Keywords: HTLV-1
ORF-I
Mutations
keywords: HTLV-1
ORF-I
Mutações
Issue Date: 2019
Publisher: Mary Ann Liebert
Citation: BORBA, Melina Mosquera Navarro et al. Assessment of Genetic Diversity of HTLV-1 ORF-I Sequences Collected from Patients with Different Clinical Profiles. Aids Research and Human Retroviruses, p. 1-4, 2019.
DOI: 10.1089/AID.2019.0127
ISSN: 0889-2229
Copyright: restricted access
Appears in Collections:BA - IGM - Artigos de Periódicos

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