Please use this identifier to cite or link to this item:
|Title:||Delayed childhood neurodevelopment and neurosensory alterations in the second year of life in a prospective cohort of ZIKV-exposed children|
Gabaglia, Claudia Raja
Carvalho, Liege M. Abreu de
Pone, Sheila M.
Zin, Andrea A.
Salles, Tania Regina S.
Cunha, Denise Cotrim da
Costa, Roozemerie Pereira
Reis, Ana Beatriz
Hasue, Renata Hydee
Aizawa, Carolina Y. P.
Genovesi, Fernanda F.
Marschik, Peter B.
Pereira, José Paulo
Gaw, Stephanie L.
Cherry, James D.
Moreira, Maria Elisabeth
|Affilliation:||Múltipla - Ver em Notas.|
|Abstract:||We report neurodevelopmental outcomes in 216 infants followed since the time of PCR-confirmed maternal Zika virus (ZIKV) infection in pregnancy during the Rio de Janeiro epidemic of 2015-2016 (refs. 1,2). Neurodevelopment was assessed by Bayley Scales of Infant and Toddler Development, third edition (Bayley-III; cognitive, language and motor domains) in 146 children and through neurodevelopment questionnaires/neurological examinations in 70 remaining children. Complete eye exams (n = 137) and hearing assessments (n = 114) were also performed. Below-average neurodevelopment and/or abnormal eye or hearing assessments were noted in 31.5% of children between 7 and 32 months of age. Among children assessed by Bayley-III, 12% scored below -2 s.d. (score <70; a score of 100 ± 2 s.d. is the range) in at least one domain; and 28% scored between -1 and -2 s.d. in any domain (scores <85-70). Language function was most affected, with 35% of 146 children below average. Improved neurodevelopmental outcomes were noted in female children, term babies, children with normal eye exams and maternal infection later in pregnancy (P = 0.01). We noted resolution of microcephaly with normal neurodevelopment in two of eight children, development of secondary microcephaly in two other children and autism spectrum disorder in three previously healthy children in the second year of life.|
|Citation:||NIELSEN-SAINES, Karin et al. Delayed childhood neurodevelopment and neurosensory alterations in the second year of life in a prospective cohort of ZIKV-exposed children. Nature Medicine, v. 25, p. 1213-1217, Aug. 2019.|
|Description:||Patrícia Brasil. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. 1 David Geffen UCLA School of Medicine, CA, Los Angeles, USA. 2 Fundação Oswaldo Cruz, Rio de Janeiro, Brazil. 3 Biomedical Research Institute of Southern California, CA, Oceanside, USA. 4Faculty of Medicine, University of São Paulo, São Paulo, Brazil. 5 Medical University of Graz, Graz, Austria. 6University Medical Center, Göttingen, Germany. 7 UCSF School of Medicine, CA, San Francisco, USA. 8State Key Laboratory of Molecular Developmental Biology, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China. 9Parkinson’s Disease Center, Beijing Institute for Brain Disorders, Beijing, China.|
|Appears in Collections:||INI - Artigos de Periódicos|
Files in This Item:
|ve_Nielsen-Saines_Karin_etal_INI_2019.pdf||1.23 MB||Adobe PDF||Request a copy|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.