Author | Machado, Gérzia Maria de Carvalho | |
Author | Leon, Leonor Laura | |
Author | Castro, Solange Lisboa de | |
Access date | 2019-09-24T13:25:39Z | |
Available date | 2019-09-24T13:25:39Z | |
Document date | 2007 | |
Citation | MACHADO, Gérzia Maria de Carvalho; LEON, Leonor Laura; CASTRO, Solange Lisboa de. Activity of Brazilian and Bulgarian propolis against different species of Leishmania. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 1, p. 73-77, Feb. 2007. | pt_BR |
ISSN | 0074-0276 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/35839 | |
Language | eng | pt_BR |
Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Leishmania | pt_BR |
Subject in Portuguese | Leishmaniose | pt_BR |
Subject in Portuguese | Própolis | pt_BR |
Subject in Portuguese | Produtos naturais | pt_BR |
Subject in Portuguese | Composição química | pt_BR |
Title | Activity of Brazilian and Bulgarian propolis against different species of Leishmania | pt_BR |
Type | Article | pt_BR |
DOI | 10.1590/s0074-02762007000100012 | |
Abstract | Extracts of propolis samples collected in Brazil and Bulgaria were assayed against four Leishmania species--Leishmania amazonensis, L. braziliensis, L. chagasi from the New World, and L. major from the Old World--associated to different clinical forms of leishmaniasis. The composition of the extracts has been previously characterized by high temperature high resolution gas chromatography coupled to mass spectrometry. Considering the chemical differences among the extracts and the behavior of the parasites, it was observed significant differences in the leishmanicidal activities with IC50/1 day values in the range of 2.8 to 229.3 microg/ml . An overall analysis showed that for all the species evaluated, Bulgarian extracts were more active than the ethanol Brazilian extract. As the assayed propolis extracts have their chemical composition determined it merits further investigation the effect of individual components or their combinations on each Leishmania species. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultra-estrutura e Biologia Celular. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Leishmania | pt_BR |
Subject | Leishmaniasis | pt_BR |
Subject | Propolis | pt_BR |
Subject | Chemical composition | pt_BR |
Subject | Natural products | pt_BR |
e-ISSN | 1678-8060 | |