Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/35839
Title: Activity of Brazilian and Bulgarian propolis against different species of Leishmania
Authors: Machado, Gérzia Maria de Carvalho
Leon, Leonor Laura
Castro, Solange Lisboa de
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultra-estrutura e Biologia Celular. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Abstract: Extracts of propolis samples collected in Brazil and Bulgaria were assayed against four Leishmania species--Leishmania amazonensis, L. braziliensis, L. chagasi from the New World, and L. major from the Old World--associated to different clinical forms of leishmaniasis. The composition of the extracts has been previously characterized by high temperature high resolution gas chromatography coupled to mass spectrometry. Considering the chemical differences among the extracts and the behavior of the parasites, it was observed significant differences in the leishmanicidal activities with IC50/1 day values in the range of 2.8 to 229.3 microg/ml . An overall analysis showed that for all the species evaluated, Bulgarian extracts were more active than the ethanol Brazilian extract. As the assayed propolis extracts have their chemical composition determined it merits further investigation the effect of individual components or their combinations on each Leishmania species.
Keywords: Leishmania
Leishmaniasis
Propolis
Chemical composition
Natural products
keywords: Leishmania
Leishmaniose
Própolis
Produtos naturais
Composição química
Issue Date: 2007
Publisher: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
Citation: MACHADO, Gérzia Maria de Carvalho; LEON, Leonor Laura; CASTRO, Solange Lisboa de. Activity of Brazilian and Bulgarian propolis against different species of Leishmania. Mem Inst Oswaldo Cruz, Rio de Janeiro, v. 102, n. 1, p. 73-77, Feb. 2007.
DOI: 10.1590/s0074-02762007000100012
ISSN: 0074-0276
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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