| Author | Costa, Gustavo Nunes de Oliveira | |
| Author | Figueiredo, Camila Alexandrina | |
| Author | Conceição, Jackson Santos | |
| Author | Strina, Agostino | |
| Author | Genser, Bernd | |
| Author | Silva, Thiago Magalhaes da | |
| Author | Neves, Neuza Maria Alcantara | |
| Author | Fiaccone, Rosemeire Leovigildo | |
| Author | Rodrigues, Laura Cunha | |
| Author | Barreto, Mauricio Lima | |
| Access date | 2019-10-09T17:03:24Z | |
| Available date | 2019-10-09T17:03:24Z | |
| Document date | 2019 | |
| Citation | COSTA, Gustavo Nunes de Oliveira et al. Genetic variants in 17q12-21 locus and childhood asthma in Brazil: Interaction with Varicella zoster virus seropositivity. Gene, v. 715, p. 1-7, 2019. | pt_BR |
| ISSN | 0378-1119 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/36304 | |
| Sponsorship | Department of Science and
Technology (DECIT, Ministry of Health), National Fund for Scientific
and Technological Development (FNDCT, Ministry of Science and
Technology), Funding of Studies and Projects (FINEP, Ministry of
Science and Technology, Brazil) and the Brazilian National Research
Council (CNPq). | pt_BR |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Asma infantil | pt_BR |
| Subject in Portuguese | Atopia | pt_BR |
| Subject in Portuguese | Varicella zoster | pt_BR |
| Subject in Portuguese | Predisposição Genética para Doença | pt_BR |
| Subject in Portuguese | Humanos | pt_BR |
| Title | Genetic variants in 17q12-21 locus and childhood asthma in Brazil: Interaction with Varicella zoster virus seropositivity | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1016/j.gene.2019.143991 | |
| Abstract | Asthma is a complex disease with worldwide public health relevance, is related to environmental causes and a genetic predisposition. The chromosomal 17q12-21 locus has been consistently demonstrated to be associated with asthma risk. The effects of variants in the 17q12-21 locus on childhood asthma were first identified in a genome wide- association study. Since that time, those findings have been replicated in different populations but not in South American populations. Objective: This study aimed to investigate the role of variants in the 17q12-21 locus on asthma in a sample of
Brazilian children.
Methods: This was a cross-sectional study conducted on a cohort of 1247 children. These analyses used 50 Single
Nucleotide Variants (SNVs) in the 17q12-21 locus were genotyped as part of a genome wide association study
(GWAS).
Results: Four SNVs (rs4065275, rs12603332, rs73985228 and rs77777702) were associated with childhood
asthma. The rs73985228 exhibited the strongest association across the different genetic models (OR, 95%CI 2.8,
1.44–3.21, p < 0.01). In an analysis that was stratified by atopy, two SNVs (rs73985228 and rs2715555) were
found to be associated with atopic and non-atopic asthma. For the first time, we observed a significant interaction
with seropositivity for the Varicella zoster virus (for rs4065275, p=0.02, and for rs12603332, p=0.04);
i.e., the association was found in those who were seropositive but not in those who were seronegative for this
virus.
Conclusions: We confirmed the associations of variants in the 17q12-21 locus with atopic and non-atopic asthma
and identified an interaction with seropositivity for the Varicella zoster virus. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Universidade Salvador. Departamento de Ciências da Saúde. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Matemática. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil. | pt_BR |
| Affilliation | University of Heidelberg. Medical Faculty Mannheim. Mannheim Institute of Public Health, Social and Preventive Medicine. Mannheim, Germany. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Matemática. Salvador, BA, Brasil. | pt_BR |
| Affilliation | London School of Hygiene and Tropical Medicine. Department of Epidemiology and Populations Health. UK | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Subject | Childhood asthma | pt_BR |
| Subject | Atopy | pt_BR |
| Subject | Varicella zoster | pt_BR |
| Subject | Genetic Predisposition to Disease | pt_BR |
| Subject | Humans | pt_BR |
| Embargo date | 2020-01-08 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
