Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/36304
Title: Genetic variants in 17q12-21 locus and childhood asthma in Brazil: Interaction with Varicella zoster virus seropositivity
Authors: Costa, Gustavo Nunes de Oliveira
Figueiredo, Camila Alexandrina
Conceição, Jackson Santos
Strina, Agostino
Genser, Bernd
Silva, Thiago Magalhaes da
Neves, Neuza Maria Alcantara
Fiaccone, Rosemeire Leovigildo
Rodrigues, Laura Cunha
Barreto, Mauricio Lima
Affilliation: Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Universidade Salvador. Departamento de Ciências da Saúde. Salvador, BA, Brasil.
Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.
Universidade Federal da Bahia. Instituto de Matemática. Salvador, BA, Brasil.
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.
University of Heidelberg. Medical Faculty Mannheim. Mannheim Institute of Public Health, Social and Preventive Medicine. Mannheim, Germany.
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.
Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Matemática. Salvador, BA, Brasil.
London School of Hygiene and Tropical Medicine. Department of Epidemiology and Populations Health. UK
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Abstract: Asthma is a complex disease with worldwide public health relevance, is related to environmental causes and a genetic predisposition. The chromosomal 17q12-21 locus has been consistently demonstrated to be associated with asthma risk. The effects of variants in the 17q12-21 locus on childhood asthma were first identified in a genome wide- association study. Since that time, those findings have been replicated in different populations but not in South American populations. Objective: This study aimed to investigate the role of variants in the 17q12-21 locus on asthma in a sample of Brazilian children. Methods: This was a cross-sectional study conducted on a cohort of 1247 children. These analyses used 50 Single Nucleotide Variants (SNVs) in the 17q12-21 locus were genotyped as part of a genome wide association study (GWAS). Results: Four SNVs (rs4065275, rs12603332, rs73985228 and rs77777702) were associated with childhood asthma. The rs73985228 exhibited the strongest association across the different genetic models (OR, 95%CI 2.8, 1.44–3.21, p < 0.01). In an analysis that was stratified by atopy, two SNVs (rs73985228 and rs2715555) were found to be associated with atopic and non-atopic asthma. For the first time, we observed a significant interaction with seropositivity for the Varicella zoster virus (for rs4065275, p=0.02, and for rs12603332, p=0.04); i.e., the association was found in those who were seropositive but not in those who were seronegative for this virus. Conclusions: We confirmed the associations of variants in the 17q12-21 locus with atopic and non-atopic asthma and identified an interaction with seropositivity for the Varicella zoster virus.
Keywords: Childhood asthma
Atopy
Varicella zoster
Genetic Predisposition to Disease
Humans
keywords: Asma infantil
Atopia
Varicella zoster
Predisposição Genética para Doença
Humanos
Issue Date: 2019
Publisher: Elsevier
Citation: COSTA, Gustavo Nunes de Oliveira et al. Genetic variants in 17q12-21 locus and childhood asthma in Brazil: Interaction with Varicella zoster virus seropositivity. Gene, v. 715, p. 1-7, 2019.
DOI: 10.1016/j.gene.2019.143991
ISSN: 0378-1119
Copyright: restricted access
Appears in Collections:BA - IGM - Artigos de Periódicos

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