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2022-01-01
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- IOC - Artigos de Periódicos [12977]
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TRYPANOSOMA CRUZI: EVECTS OF INFECTION ON CATHEPSIN D ACTIVITY IN THE MIDGUT OF RHODNIUS PROLIXUS
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Abstract
Cathepsin D activity was estimated in midgut homogenates from Rhodnius prolixus, uninfected and experimentally infected with Trypanosoma
cruzi, at diVerent times after blood ingestion. No enzyme activity was found in the anterior midgut and rectum. In the posterior
midgut, enzyme activity was found both in lumen and wall. In starved uninfected insects, in lumen and wall, cathepsin D activity was
high, decreasing to a constant rate at 1–15 days after feeding. In insects infected with T. cruzi cathepsin D activity increased 1 and 3 days
after blood meal. We suggest that these changes in cathepsin D activity in R. prolixus posterior midgut are due to the establishment of
T. cruzi infection.
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