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AutorHolguín, Angela Victoria
AutorCárdenas, Pablo
AutorPeñaranda, Catalina Prada-
AutorLeite, Laura Rabelo
AutorBuitrago, Camila
AutorClavijo, Viviana
AutorOliveira, Guilherme Corrêa de
AutorLeekitcharoenphon, Pimlapas
AutorAarestrup, Frank Møller
AutorVives, Martha J.
Fecha de acceso2019-11-06T14:01:23Z
Fecha de disponibilización2019-11-06T14:01:23Z
Fecha de publicación2019
ReferenciaHOLGUÍN, Angela Victoria et al. Host Resistance, Genomics and Population Dynamics in a Salmonella Enteritidis and Phage System. Viruses, v. 11, n. 2, p. 1-11, 2019.pt_BR
ISSN1999-4915pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/36893
Idiomaengpt_BR
EditorMDPIpt_BR
Derechos de autorrestricted accesspt_BR
TítuloHost Resistance, Genomics and Population Dynamics in a Salmonella Enteritidis and Phage Systempt_BR
Tipo del documentoArticle
DOI10.3390/v11020188
Resumen en InglésBacteriophages represent an alternative solution to control bacterial infections. When interacting, bacteria and phage can evolve, and this relationship is described as antagonistic coevolution, a pattern that does not fit all models. In this work, the model consisted of a microcosm of Salmonella enterica serovar Enteritidis and jSan23 phage. Samples were taken for 12 days every 48 h. Bacteria and phage samples were collected; and isolated bacteria from each time point were challenged against phages from previous, contemporary, and subsequent time points. The phage plaque tests, with the genomics analyses, showed a mutational asymmetry dynamic in favor of the bacteria instead of antagonistic coevolution. This is important for future phage-therapy applications, so we decided to explore the population dynamics of Salmonella under different conditions: pressure of one phage, a combination of phages, and phages plus an antibiotic. The data from cultures with single and multiple phages, and antibiotics, were used to create a mathematical model exploring population and resistance dynamics of Salmonella under these treatments, suggesting a nonlethal, growth-inhibiting antibiotic may decrease resistance to phage-therapy cocktails. These data provide a deep insight into bacterial dynamics under different conditions and serve as additional criteria to select phages and antibiotics for phage-therapy.pt_BR
AfiliaciónDepartment of Biological Sciences. Universidad de Los Andes. Bogotá, Colombia.pt_BR
AfiliaciónDepartment of Biological Sciences. Universidad de Los Andes. Bogotá, Colombia.pt_BR
AfiliaciónDepartment of Biological Sciences. Universidad de Los Andes. Bogotá, Colombia.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.pt_BR
AfiliaciónDepartment of Biological Sciences. Universidad de Los Andes. Bogotá, Colombia.pt_BR
AfiliaciónDepartment of Biological Sciences. Universidad de Los Andes. Bogotá, Colombia.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil / Instituto Tecnológico Vale. Belém, PA, Brazil.pt_BR
AfiliaciónResearch Group for Genomic Epidemiology. National Food Institute. Technical University of Denmark. Lyngby, Denmark.pt_BR
AfiliaciónResearch Group for Genomic Epidemiology. National Food Institute. Technical University of Denmark. Lyngby, Denmark.pt_BR
AfiliaciónDepartment of Biological Sciences. Universidad de Los Andes. Bogotá, Colombia.pt_BR
Palavras clave en InglêsPhage-therapypt_BR
Palavras clave en InglêsSalmonella Enteritidispt_BR
Palavras clave en InglêsBacteria-phage coevolutionpt_BR
Palavras clave en InglêsAntibioticspt_BR
Palavras clave en InglêsBacterial resistancept_BR
Fecha de embargo2022-01-01


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