Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/36957
Title: Spontaneous renal adenocarcinoma in a Syrian hamster (Mesocricetus auratus): frequency, morphological and immunohistochemical findings
Authors: Trotte, Marcele N. de Sousa
Pinto, Luciana W.
Santos, Belmira F. dos
Menezes, Rodrigo C.
Tortelly, Rogerio
Affilliation: Universidade Federal Fluminense. Faculdade de Veterinária. Departamento de Patologia e Clínica Veterinária. Niterói, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Centro de Criação de Animais de Laboratório. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil.
Universidade Federal Fluminense. Faculdade de Veterinária. Departamento de Patologia e Clínica Veterinária. Niterói, RJ, Brasil.
Abstract: A spontaneous adenocarcinoma occurred in one (0.22%) adult male Syrian hamster out of 443 necropsied from a breeding animal house of the state of Rio de Janeiro, Brazil. Gross inspection showed that the renal neoplasm consisted of a unilateral single white nodule of hard consistency located in the cortex, measuring 5 mm in diameter. Microscopically, the renal epithelial cells were markedly pleomorphic and presented an abundant granular eosinophilic cytoplasm. Cells were cuboidal and mainly formed trabeculae of various widths without a lumen and also formed solid areas. There were necrotic areas and three mitotic figures per 30 high-power fields. No intravascular invasion or metastasis was observed. Positive expression of vimentin and negative expression of cytokeratin 7, pan-cytokeratin and CD10 were observed in the tumor. The histopathology and immunohistochemical profile of the renal tumor suggested the diagnosis of the eosinophilic variant of adenocarcinoma, which was reported for the first time in this species.
Keywords: Mesocricetus auratus
Renal adenocarcinoma
Immunohistochemistry,
Neoplasia
Issue Date: 2010
Publisher: Associação Brasileira de Patologia Veterinária
Citation: TROTTE, Marcele N. de Sousa et al. Spontaneous renal adenocarcinoma in a Syrian hamster (Mesocricetus auratus): frequency, morphological and immunohistochemical findings. Brazilian Journal of Veterinary Pathology, v. 3, n. 2, p. 123-126, 2010.
ISSN: 1983-0246
Copyright: open access
Appears in Collections:ICTB - Artigos de Periódicos
INI - Artigos de Periódicos

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