Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/36960
Title: Antitubercular activity of new coumarins
Authors: Cardoso, Silvia H.
Barreto, Milena B.
Lourenço, Maria C. S.
Henriques, Maria das Graças M. de O.
Candéa, André L. P.
Kaiser, Carlos R.
Souza, Marcus V. N. de
Affilliation: Universidade Federal de Alagoas. Campus Arapiraca. Arapiraca, AL, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Química. Departamento de Química Orgânica. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Pesquisas Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Química. Departamento de Química Orgânica. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.
Abstract: The present article describes a series of 21 N ¢-benzylidene-2-oxo-2H-chromene-3-carbohydrazides 4a–4v, which were synthesized and evaluated for their cell viabilities in non-infected and Mycobacterium bovis Bacillus Calmette–Guerin-infected macrophages. Subsequently, the non-cytotoxic compounds 4c, 4g, 4h, 4j, 4l and 4t were assessed against Mycobacterium tuberculosis ATCC 27294 using the microplate Alamar Blue assay and the activity expressed as the minimum inhibitory concentration in lg/mL. These compounds exhibited a significant activity (50–100 lg/mL) when compared to the first-line drugs, such as pyrazinamide (PZA >100 lg/mL). These results could be considered a good starting point for further studies to develop new lead compounds to treat multidrug-resistant tuberculosis.
Keywords: Coumarins
Drugs
N'-acylhydrazones
Tuberculosis
Issue Date: 2011
Publisher: Wiley
Citation: CARDOSO, Silvia H. et al. Antitubercular activity of new coumarins. Chemical Biology and Drug Design, v. 77, p. 489-493, 2011.
DOI: 10.1111/j.1747-0285.2011.01120.x
ISSN: 1747-0277
Copyright: restricted access
Appears in Collections:Farmanguinhos - Artigos de Periódicos
INI - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
ve_Cardoso_Silvia_etal_INI_2011.pdf171.61 kBAdobe PDF    Request a copy



FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.