Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/3719
Title: Histopathological study of experimental and natural infections by Trypanosoma cruzi in Didelphis marsupialis
Authors: Carreira, João Carlos Araujo
Jansen, Ana Maria
Deane, Maria P.
Lenzi, Henrique Leonel
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia de Tripanosomatídeos. Departamento de Protozoologia. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia de Tripanosomatídeos. Departamento de Protozoologia. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia de Tripanosomatídeos. Departamento de Protozoologia. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil
Abstract: Didelphis marsupialis, the most important sylvatic reservoir of Trypanosoma cruzi, can also maintain in their anal scent glands the multiplicative forms only described in the intestinal tract of triatomine bugs. A study of 21 experimentally and 10 naturally infected opossums with T. cruzi was undertaken in order to establish the histopathological pattern under different conditions. Our results showed that the inflammation was predominantly lymphomacrophagic and more severe in the naturally infected animals but never as intense as those described in Chagas' disease or in other animal models. The parasitism in both groups was always mild with very scarce amastigote nests in the tissues. In the experimentally infected animals, the inflammation was directly related to the presence of amastigotes nests. Four 24 days-old animals, still in embryonic stage, showed multiple amastigotes nests and moderate inflammatory reactions, but even so they survived longer and presented less severe lesions than experimentally infected adult mice. Parasites were found in smooth, cardiac and/or predominantly striated muscles, as well as in nerve cells. Differing from the experimentally infected opossums parasitism in the naturally infected animals predominated in the heart, esophagus and stomach. Parasitism of the scent glands did not affect the histopathological pattern observed in extraglandular tissues
Keywords: Trypanosoma cruzi - patology
Didelphis marsupialis
Opossum - parasitology
DeCS: Trypanosoma cruzi - patologia
Trichosurus - parasitologia
Didelphis
Issue Date: 1996
Citation: CARREIRA, João Carlos Araujo et al. Histopathological study of experimental and natural infections by Trypanosoma cruzi in Didelphis marsupialis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro,v.91, n.5, p.609-618, 1996.
Description: Acknowledgments to Luzia Fatima Gonçalves Caputo for technical assistance.
DOI: http://dx.doi.org/10.1590/S0074-02761996000500012
ISSN: 0074-0276
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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