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SIMULTANEOUS LYMPH NODE INVOLVEMENT BY CASTLEMAN DISEASE AND KAPOSI SARCOMA
Human herpesvirus 8
Giant lymph node hyperplasia
Herpesviridae infections
Virus latency
Male human
Adults
Case reports
Affilliation
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Abstract
Both multicentric Castleman disease and Kaposi sarcoma are more frequently observed in HIV infected patients. The coexistence of these Human herpesvirus 8 related lesions, in the same tissue, has been observed, but literature reports are scant. On the other hand, the expression of HHV-8-LANA-1 is easily demonstrable by immunohistochemistry. This has been shown to be a powerful tool for the diagnosis of these entities. The aim of this report is to communicate our experience with a case of multicentric Castleman disease occurring in the setting of HIV infection, which demonstrated microscopic Kaposi sarcoma in the same lymph node during the pathological work-up.
Keywords
Kaposi SarcomaHuman herpesvirus 8
Giant lymph node hyperplasia
Herpesviridae infections
Virus latency
Male human
Adults
Case reports
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