| Author | Kuriyama, Sergio Noboru | |
| Author | De-Oliveira, Ana Cecilia Amado Xavier | |
| Author | Fidalgo-Neto, Antonio Augusto | |
| Author | Paumgartten, Francisco Jose Roma | |
| Access date | 2019-11-25T17:20:23Z | |
| Available date | 2019-11-25T17:20:23Z | |
| Document date | 2000 | |
| Citation | KURIYAMA, Sergio Noboru et al . Effects of pregnancy and protein-energy malnutrition on monooxygenase O-dealkylation activity in rat liver microsomes. Brazilian Journal of Medical and Biological Research, v. 33, n. 1, p. 103-109, 2000. | pt_BR |
| ISSN | 0100-879X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/37364 | |
| Language | eng | pt_BR |
| Publisher | Associação Brasileira de Divulgação Científica | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Família 11 do Citocromo P450 | pt_BR |
| Subject in Portuguese | Oxigenases de Função Mista | pt_BR |
| Subject in Portuguese | Desnutrição | pt_BR |
| Subject in Portuguese | Gravidez | pt_BR |
| Subject in Portuguese | Metabolismo | pt_BR |
| Title | Effects of pregnancy and protein-energy malnutrition on monooxygenase O-dealkylation activity in rat liver microsomes | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1590/S0100-879X2000000100014 | |
| Abstract | Xenobiotic metabolism is influenced by a variety of physiological and environmental factors including pregnancy and nutritional status of the individual. Pregnancy has generally been reported to cause a depression of hepatic monooxygenase activities. Low-protein diets and protein-energy malnutrition have also been associated with a reduced activity of monooxygenases in nonpregnant animals. We investigated the combined effects of pregnancy and protein-energy malnutrition on liver monooxygenase O-dealkylation activity. On pregnancy day 0 rats were assigned at random to a group fed ad libitum (well-nourished, WN) or to a malnourished group (MN) which received half of the WN food intake (12 g/day). WN and MN rats were killed on days 0 (nonpregnant), 11 or 20 of pregnancy and ethoxy- (EROD), methoxy- (MROD) and penthoxy- (PROD) resorufin O-dealkylation activities were measured in liver microsomes. Only minor changes in enzyme activities were observed on pregnancy day 11, but a clear-cut reduction of monooxygenase activities (pmol resorufin min-1 mg protein-1) was noted near term (day 0 vs 20, means ± SD, Student t-test, P<0.05) in WN (EROD: 78.9 ± 15.1 vs 54.6 ± 10.2; MROD: 67.8 ± 10.0 vs 40.9 ± 7.2; PROD: 6.6 ± 0.9 vs 4.3 ± 0.8) and in MN (EROD: 89.2 ± 23.9 vs 46.9 ± 15.0; MROD: 66.8 ± 13.8 vs 27.9 ± 4.4; PROD: 6.3 ± 1.0 vs 4.1 ± 0.6) dams. On pregnancy day 20 MROD was lower in MN than in WN dams. Malnutrition did not increase the pregnancy-induced reduction of EROD and PROD activities. Thus, the present results suggest that the activities of liver monooxygenases are reduced in near-term pregnancy and that protein-energy malnutrition does not alter EROD or PROD in pregnant rats. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública. Laboratório de Toxicologia Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública. Laboratório de Toxicologia Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública. Laboratório de Toxicologia Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública. Laboratório de Toxicologia Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Cytochrome P450 | pt_BR |
| Subject | Monooxygenases | pt_BR |
| Subject | Xenobiotic Metabolism | pt_BR |
| Subject | Undernutrition | pt_BR |
| Subject | Gestation | pt_BR |
| Subject | Biotransformation | pt_BR |
| DeCS | Cytochrome P450 Family 11 | pt_BR |
| DeCS | Mixed Function Oxygenases Malnutrition | pt_BR |
| DeCS | Pregnancy | pt_BR |
| DeCS | Metabolism | pt_BR |
| e-ISSN | 1414-431X | |
| xmlui.metadata.dc.subject.ods | 02 Fome zero e agricultura sustentável | |
