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EFFECTS OF PREGNANCY AND PROTEIN-ENERGY MALNUTRITION ON MONOOXYGENASE O-DEALKYLATION ACTIVITY IN RAT LIVER MICROSOMES
Oxigenases de Função Mista
Desnutrição
Gravidez
Metabolismo
Monooxygenases
Xenobiotic Metabolism
Undernutrition
Gestation
Biotransformation
Author
Affilliation
Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública. Laboratório de Toxicologia Ambiental. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública. Laboratório de Toxicologia Ambiental. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública. Laboratório de Toxicologia Ambiental. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública. Laboratório de Toxicologia Ambiental. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública. Laboratório de Toxicologia Ambiental. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública. Laboratório de Toxicologia Ambiental. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública. Laboratório de Toxicologia Ambiental. Rio de Janeiro, RJ, Brasil.
Abstract
Xenobiotic metabolism is influenced by a variety of physiological and environmental factors including pregnancy and nutritional status of the individual. Pregnancy has generally been reported to cause a depression of hepatic monooxygenase activities. Low-protein diets and protein-energy malnutrition have also been associated with a reduced activity of monooxygenases in nonpregnant animals. We investigated the combined effects of pregnancy and protein-energy malnutrition on liver monooxygenase O-dealkylation activity. On pregnancy day 0 rats were assigned at random to a group fed ad libitum (well-nourished, WN) or to a malnourished group (MN) which received half of the WN food intake (12 g/day). WN and MN rats were killed on days 0 (nonpregnant), 11 or 20 of pregnancy and ethoxy- (EROD), methoxy- (MROD) and penthoxy- (PROD) resorufin O-dealkylation activities were measured in liver microsomes. Only minor changes in enzyme activities were observed on pregnancy day 11, but a clear-cut reduction of monooxygenase activities (pmol resorufin min-1 mg protein-1) was noted near term (day 0 vs 20, means ± SD, Student t-test, P<0.05) in WN (EROD: 78.9 ± 15.1 vs 54.6 ± 10.2; MROD: 67.8 ± 10.0 vs 40.9 ± 7.2; PROD: 6.6 ± 0.9 vs 4.3 ± 0.8) and in MN (EROD: 89.2 ± 23.9 vs 46.9 ± 15.0; MROD: 66.8 ± 13.8 vs 27.9 ± 4.4; PROD: 6.3 ± 1.0 vs 4.1 ± 0.6) dams. On pregnancy day 20 MROD was lower in MN than in WN dams. Malnutrition did not increase the pregnancy-induced reduction of EROD and PROD activities. Thus, the present results suggest that the activities of liver monooxygenases are reduced in near-term pregnancy and that protein-energy malnutrition does not alter EROD or PROD in pregnant rats.
Keywords in Portuguese
Família 11 do Citocromo P450Oxigenases de Função Mista
Desnutrição
Gravidez
Metabolismo
Keywords
Cytochrome P450Monooxygenases
Xenobiotic Metabolism
Undernutrition
Gestation
Biotransformation
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