| Author | Kauffman, Carla | |
| Author | Giacomin, Ana Caroline | |
| Author | Arossi, Kelen | |
| Author | Pacheco, Leandra Andressa | |
| Author | Hoehne, Lucélia | |
| Author | Freitas, Elisete Maria de | |
| Author | Machado, Gérzia Maria de Carvalho | |
| Author | Cavalheiro, Marilene Marcuzzo do Canto | |
| Author | Gnoatto, Simone Cristina Baggio | |
| Author | Ethur, Eduardo Miranda | |
| Access date | 2019-11-26T11:22:40Z | |
| Available date | 2019-11-26T11:22:40Z | |
| Document date | 2019 | |
| Citation | KAUFFMANN, Carla et al. Antileishmanial in vitro activity of essential oil from Myrciaria plinioides, a native species from Southern Brazil. Brazilian Journal of Pharmaceutical Sciences, São Paulo, v. 55, p. 1-8, 2019. | pt_BR |
| ISSN | 2175-9790 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/37371 | |
| Language | eng | pt_BR |
| Publisher | Universidade de São Paulo, Faculdade de Ciências Farmacêuticas | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Leishmania infantum | pt_BR |
| Subject in Portuguese | Myrciaria plinioides | pt_BR |
| Subject in Portuguese | Leishmania amazonensis | pt_BR |
| Subject in Portuguese | Atividade Antileishmanial | pt_BR |
| Title | Antileishmanial in vitro activity of essential oil from Myrciaria plinioides, a native species from Southern Brazil | pt_BR |
| Type | Article | |
| DOI | 10.1590/s2175-97902019000217584 | |
| Abstract | In South American folk medicine members of the genus Myrciaria are used for the treatment of malaria, diarrhoea, asthma, inflammation and post-partum uterine cleansing. The aim of this work was to evaluate its antileishmanial properties (in vitro) of essential oil derived from leaves of Myrciaria plinioides D. Legrand, a plant species that is native in South of Brazil. The essential oil was obtained by hydro-distillation using fresh leaves of M. plinioides. The chemical composition of this essential oil (MPEO, M. plinioides essential oil) was determined by gas chromatography coupled to mass spectrometry (GC‑MS). MPEO was assayed in vitro for antileishmanial properties against promastigotes of Leishmania amazonensis and Leishmania infantum, and for cytotoxicity against murine peritoneal macrophages. The MPEO comprised 66 components and was rich in oxygenated sesquiterpenes (82.66%) containing spathulenol (21.12%) as its major constituent. The MPEO was effective against L. amazonensis with IC50 value of 14.16 ± 7.40 µg/mL, while against L. infantum the IC50 value was higher with 101.50 ± 5.78 µg/mL. The MPEO showed significant activity against L. amazonensis, and presented a selectivity index (SI) of 6.60. The results suggest that the essential oil from leaves of M. plinioides is a promising source for new antileishmanial agents against L. amazonensis. | pt_BR |
| Affilliation | Universidade do Vale do Taquari. Centro de Ciências Biológicas e da Saúde. Lajeado, RS, Brasil. | pt_BR |
| Affilliation | Universidade do Vale do Taquari. Centro de Ciências Biológicas e da Saúde. Lajeado, RS, Brasil. | pt_BR |
| Affilliation | Universidade do Vale do Taquari. Centro de Ciências Biológicas e da Saúde. Lajeado, RS, Brasil. | pt_BR |
| Affilliation | Universidade do Vale do Taquari. Centro de Ciências Biológicas e da Saúde. Lajeado, RS, Brasil. | pt_BR |
| Affilliation | Universidade do Vale do Taquari. Centro de Ciências Exatas e Tecnológicas. Lajeado, RS, Brasil. | pt_BR |
| Affilliation | Universidade do Vale do Taquari. Centro de Ciências Biológicas e da Saúde. Lajeado, RS, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio Grande do Sul. Faculdade de Farmácia. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Leishmania infantum | pt_BR |
| Subject | Myrciaria plinioides | pt_BR |
| Subject | Leishmania amazonensis | pt_BR |
| Subject | Antileishmanial activity | pt_BR |
