Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/37371
Title: Antileishmanial in vitro activity of essential oil from Myrciaria plinioides, a native species from Southern Brazil
Authors: Kauffman, Carla
Giacomin, Ana Caroline
Arossi, Kelen
Pacheco, Leandra Andressa
Hoehne, Lucélia
Freitas, Elisete Maria de
Machado, Gérzia Maria de Carvalho
Cavalheiro, Marilene Marcuzzo do Canto
Gnoatto, Simone Cristina Baggio
Ethur, Eduardo Miranda
Affilliation: Universidade do Vale do Taquari. Centro de Ciências Biológicas e da Saúde. Lajeado, RS, Brasil.
Universidade do Vale do Taquari. Centro de Ciências Biológicas e da Saúde. Lajeado, RS, Brasil.
Universidade do Vale do Taquari. Centro de Ciências Biológicas e da Saúde. Lajeado, RS, Brasil.
Universidade do Vale do Taquari. Centro de Ciências Biológicas e da Saúde. Lajeado, RS, Brasil.
Universidade do Vale do Taquari. Centro de Ciências Exatas e Tecnológicas. Lajeado, RS, Brasil.
Universidade do Vale do Taquari. Centro de Ciências Biológicas e da Saúde. Lajeado, RS, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio Grande do Sul. Faculdade de Farmácia. Porto Alegre, RS, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil.
Abstract: diarrhoea, asthma, inflammation and post-partum uterine cleansing. The aim of this work was to evaluate its antileishmanial properties (in vitro) of essential oil derived from leaves of Myrciaria plinioides D. Legrand, a plant species that is native in South of Brazil. The essential oil was obtained by hydro-distillation using fresh leaves of M. plinioides. The chemical composition of this essential oil (MPEO, M. plinioides essential oil) was determined by gas chromatography coupled to mass spectrometry (GC‑MS). MPEO was assayed in vitro for antileishmanial properties against promastigotes of Leishmania amazonensis and Leishmania infantum, and for cytotoxicity against murine peritoneal macrophages. The MPEO comprised 66 components and was rich in oxygenated sesquiterpenes (82.66%) containing spathulenol (21.12%) as its major constituent. The MPEO was effective against L. amazonensis with IC50 value of 14.16 ± 7.40 μg/mL, while against L. infantum the IC50 value was higher with 101.50 ± 5.78 μg/mL. The MPEO showed significant activity against L. amazonensis, and presented a selectivity index (SI) of 6.60. The results suggest that the essential oil from leaves of M. plinioides is a promising source for new antileishmanial agents against L. amazonensis.
Keywords: Leishmania infantum
Myrciaria plinioides
Leishmania amazonensis
Antileishmanial activity
keywords: Leishmania infantum
Myrciaria plinioides
Leishmania amazonensis
Atividade Antileishmanial
Issue Date: 2019
Publisher: Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Citation: KAUFFMANN, Carla et al. Antileishmanial in vitro activity of essential oil from Myrciaria plinioides, a native species from Southern Brazil. Braz. J. Pharm. Sci., São Paulo, v. 55, e17584, 8p, 2019.
DOI: 10.1590/s2175-97902019000217584
ISSN: 2175-9790.
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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