Inducible nitric oxide synthase (iNOS) expression in monocytes during acute Dengue Fever in patients and during in vitro infection

Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.
Universidade Federal Fluminense. Hospital Antonio Pedro. Departamento de Clínica Médica. Niterói, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Pesquisas Clínicas Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.

Abstract

Mononuclear phagocytes are considered to be main targets for Dengue Virus (DENV) replication. These cells are activated after infection, producing proinflammatory mediators, including tumournecrosis factor-α, which has also been detected in vivo. Nitric oxide (NO), usually produced by activated mononuclear phagocytes, has antimicrobial and antiviral activities.

Keywords in Portuguese

Óxido nítrico sintase
Monócitos
Febre aguda
Dengue
Infecção in vitro

Keywords

Nitric oxide synthase
Monocytes
Acute dengue fever
In vitro infection

Publisher

BioMed Central

Citation

SOUZA, Patríicia C. F. Neves et al. Inducible nitric oxide synthase (iNOS) expression in monocytes during acute Dengue Fever in patients and during in vitro infection. BMC Infectious Diseases, v. 5, n. 64, p. 1-12, 2005.

DOI

10.1186/1471-2334-5-64

ISSN

1471-2334

Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/37748

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Open access

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