Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/37788
Title: Deciphering the Role Played by Autophagy in Leishmania Infection
Authors: Veras, Patricia Sampaio Tavares
Menezes, Juliana Perrone Bezerra de
Dias, Beatriz Rocha Simões
Affilliation: Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Parasito-Hospedeiro e Epidemiologia. Salvador, BA, Brasil / National Institute of Science and Technology of Tropical Diseases. Salvador, BA, Brazil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Parasito-Hospedeiro e Epidemiologia. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Parasito-Hospedeiro e Epidemiologia. Salvador, BA, Brasil.
Abstract: In recent decades, studies have shown that, depending on parasite species and host background, autophagy can either favor infection or promote parasite clearance. To date, relatively few studies have attempted to assess the role played by autophagy in Leishmania infection. While it has been consistently shown that Leishmania spp. induce autophagy in a variety of cell types, published results regarding the effects of autophagic modulation on Leishmania survival are contradictory. The present review, after a short overview of the general aspects of autophagy, aims to summarize the current body of knowledge surrounding how Leishmania spp. adaptively interact with macrophages, the host cells mainly involved in controlling leishmaniasis. We then explore the scarce studies that have investigated interactions between these parasite species and the autophagic pathway, and finally present a critical perspective on how autophagy influences infection outcome.
Keywords: Autophagy
Leishmania
LC3
Macrophages
Phagocytosis
Leishmaniasis
Parasitophorous vacuoles
keywords: Autofagia
Leishmania
LC3
Macrófagos
Fagocitose
Leishmaniose
Vacúolos parasitóforos
Issue Date: 2019
Publisher: Frontiers Media
Citation: VERAS, Patricia Sampaio Tavares; MENEZES, Juliana Perrone Bezerra de; DIAS, Beatriz Rocha Simões. Deciphering the role played by autophagy in Leishmania Infection. Frontiers in Immunology, v. 10, p. 1-11, Nov. 2019.
DOI: 10.3389/fimmu.2019.02523
ISSN: 1664-3224
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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