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MOLECULAR EVIDENCE OF HTLV-1 INTRAFAMILIAL TRANSMISSION IN A NON-ENDEMIC AREA IN ARGENTINA
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National University of Cordoba. School of Medicine. Virology Institute. Laboratory of Human Lymphotropic Viruses. Cordoba, Argentina.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, Brasil.
National University of Cordoba. School of Medicine. Virology Institute. Laboratory of Human Lymphotropic Viruses. Cordoba, Argentina.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, Brasil.
National University of Cordoba. School of Medicine. Virology Institute. Laboratory of Human Lymphotropic Viruses. Cordoba, Argentina.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, Brasil.
National University of Cordoba. School of Medicine. Virology Institute. Laboratory of Human Lymphotropic Viruses. Cordoba, Argentina.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, Brasil.
National University of Cordoba. School of Medicine. Virology Institute. Laboratory of Human Lymphotropic Viruses. Cordoba, Argentina.
Abstract
In the North of Argentina, an endemic area for HTLV-1, intrafamilial transmission of this virus has been observed. The HTLV-1 status in 13 family members of a seropositive blood donor from the central region of Argentina (non-endemic area) was investigated. According to serological and molecular assays, four members of this family (the blood donor, the husband, a son, and a daughter-in-law) proved to be HTLV-1 positive. LTR, tax, and env sequences from the provirus infecting the family members were identical. This strongly suggests the intrafamilial transmission of the virus. This study demonstrated intrafamilial transmission of HTLV-1 in a non-endemic area of Argentina.
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