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ZIKAPLAN: ADDRESSING THE KNOWLEDGE GAPS AND WORKING TOWARDS A RESEARCH PREPAREDNESS NETWORK IN THE AMERICAS
Guillain-Barré syndrome
Zika
Birth defect
Congenital Zika syndrome
Encephalitis
Epidemic preparedness
Microcephaly
Research capacity building
Sustainability
Zika virus
Anormalidades Congênitas
Encefalite
Epidemias
Microcefalia
Fortalecimento Institucional
Avaliação de Programas e Projetos de Saúde
aDepartment of Epidemiology and Global Health, Umeå University, Umeå, Sweden; bLondon School of Hygiene & Tropical Medicine, London, UK; cDepartamento de Medicina Tropical, Universidade Federal de Pernambuco, Recife, Brasil; dDepartamento de Medicina Interna, Universidade de Pernambuco, Recife, Brasil; eInstituto Aggeu Magalhães, Fundação Oswaldo Cruz, Recife, Brasil; fDepartamento de Medicina Social, Universidade Federal de Pernambuco, Recife, Brasil; gInstituto de Ciências Biológicas, Universidade de Pernambuco, Recife, Brasil; hInstituto Fernandes Figueira – Fundação Oswaldo Cruz, Rio de Janeiro, Brasil; iInstituto de Patologia Tropical e Saúde Publica, Universidade Federal de Goiás, Goiânia, Brasil; jInstitute of Infection and Global Health, The University of Liverpool, Liverpool, UK; kDepartments of Neurology and Immunology, Erasmus Universitair Medisch Centrum Rotterdam, The Netherlands; lJohns Hopkins University, Baltimore, MD, USA; mUniversidad del Valle, Colombia; nLaboratório de Flavivírus, Instituto Oswaldo Cruz, Brazil; oDepartment of Microbiology, Immunology and Transplantation, KU Leuven, Rega Institute of Medical Research, Leuven, Belgium; pInstitute of Tropical Medicine, Antwerp, Belgium; qInstitute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, UK; rInsitituto Medicina Tropical, Pedro Kouri, Cuba; sDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, NC, USA; tDepartmento del Medicina, Fundacion Universidad del Norte, Barranquilla, Colombia; uDivision of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA; vDepartment of Medicine, University of California San Diego, La Jolla, CA, USA; wInsect-Virus Interactions Unit, Institut Pasteur, UMR2000, CNRS, Paris, France; xMaternal Fetal and Infant Research Centre, Institute of Nursing and Health Research, Ulster University, Newtownabbey, UK; yPopulation Health Research Institute, St George’s, University of London, London, UK; zAssociação Técnico-Científica Estudo Colaborativo Latino Americano de Malformações Congênitas (ECLAMC) no Departmento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; aaHospital Federal dos Servidores do Estado, Rio de Janeiro, Brazil; bbHospital da Restauração, Recife, Brazil; ccOswaldo Cruz Foundation, Recife, Brazil; ddInstituto Butantan, Brazil; eePediatrics Department, Medical School of University of Sao Paulo, Sao Paulo, Brazil; ffThe Global Health Network, Masters and Scholars of the University of Oxford, Oxford, UK; Annelies Wilder-Smith, Raman Preet, Karl-Erik Renhorn, Joacim Rocklöv, Niklas Arnberg, John Kinsman, David Persson, Stefan Nord, Lena Mustonen, Sara Forsberg (#1 Umeå University, Sweden); Elizabeth B. Brickley, Laura C. Rodrigues, Ludmila Lobkowicz, Rosanna Peeling, Debi Boeras, Andrew K. Falconar, Michael Gaunt, Kathleen M O’Reilly, James Logan, Grace Power, Thomas Ant, Laith Yakob, Hannah Kuper, Neal Alexander (#2 London School of Hygiene & Tropical Medicine, UK); Hugh J. Willison, Julia M. Edgar, Susan C. Barnett (#3 University of Glasgow, UK); Trudie Lang, Nina Jamieson, Bonny Baker, Liam Boggs (#4 University of Oxford, UK); Joan K Morris (#5 Queen Mary University of London, UK); Helen Dolk, Leke Aminkeng, Katy Karnell (#6 Ulster University, UK); Johan Neyts, Suzanne Kaptein, Kai Dallmeier (#7 Katholieke Universiteit Leuven, The Netherlands); Bart C. Jacobs, Sonja E. Leonhard, Melissa Mandarakas (#8Erasmus Universitair Medisch Centrum, The Netherlands); Louis Lambrechts, Fabian Aubry (#9 Institut Pasteur, France); Claudia Romero-Vivas (#10 Fundacion Universidad del Norte, Colombia); Carlos Pardo Villamizar, Lyda Osorio (#11 Universidad del Valle, Colombia); Koren Wolman-Tardy, Margaux Lucini, Jason Soffe, Florence Pradel, Sebasitan Quesney, Richard Vaux (#12 Fondation Mérieux, France); Tom Solomon, Suzannah Lant, Louise Cooper, Mike J Griffiths, Lance Turtle, Lisa Ng, Ravi Mehta, Raquel Madialdea-Carrera, (#13 University of Liverpool, UK); Alessandro Sette, Daniela Weiskopf (#14 La Jolla Institute for Allergy and Immunology, USA); Aravinda M. de Silva, Stefan Matz (#15 University of North Carolina at Chapel Hill, USA); Ralph Huits, Kevin K. Ariën, Liselotte Cnops (#16 Prins Leopald Instituut voor Tropische Geneeskunde, Belgium); Eduardo Massad, Esper Kallas, Amilton A Barreira (#17 Fundacao de Apoio a Universidade de Sao Paulo, Brazil); Alexander R. Precioso, Ricardo Palacios Gomez, Beatriz da Costa Thome (#18 Instituto Butantan, Brazil); Ieda Orioli, Daniel Mattos (#19 Associação Técnico-Científica Estudo Colaborativo Latino Americano de Malformações Congênitas (ECLAMC), Brazil); Ana Maria Bispo de Filippis, David Brown, Rafael Freitas de Oliveira Franca, Maria E Moreira, Zilton Vasconselos, Celina M Turchi, Ernesto TA Marques Jr., Wayner V. de Souza (#20 Fundacao Oswaldo Fiocruz, Brazil); Maria G. Guzman, José Luis Pelegrino, Mayling Vera Alvarez, Alicia Reyes Jiménez (#21 Instituto Medicina Tropical Pedro Kouri, Cuba); Amadou A Sall, Cheikh Tidiane Diagne (#22 Institut Pasteur de Dakar, Senegal); Christoph Hatz, Andreas Neumayr; Pie Mueller (#23 Schweizerisches Tropen-und Public Health-Institut, Switzerland); In-Kyu Yoon (#24 International Institute of Vaccine, S Korea); Ricardo A. A. Ximenes, Thália V. Barreto de Araújo, Celina M Turchi Martelli, Demócrito D. B. Miranda-Filho, Ulisses R. Montarroyos, Marília D. Turchi, Luiza Emylce Pelá Rosado (#25 Universidade Federal de Pernambuco, Brazil).
Author
Affilliation
Abstract
Zika Preparedness Latin American Network (ZikaPLAN) is a research consortium funded by the European Commission to address the research gaps in combating Zika and to establish a sustainable network with research capacity building in the Americas. Here we present a report on ZikaPLAN`s mid-term achievements since its initiation in October 2016 to June 2019, illustrating the research objectives of the 15 work packages ranging from virology, diagnostics, entomology and vector control, modelling to clinical cohort studies in pregnant women and neonates, as well as studies on the neurological complications of Zika infections in adolescents and adults. For example, the Neuroviruses Emerging in the Americas Study (NEAS) has set up more than 10 clinical sites in Colombia. Through the Butantan Phase 3 dengue vaccine trial, we have access to samples of 17,000 subjects in 14 different geographic locations in Brazil. To address the lack of access to clinical samples for diagnostic evaluation, ZikaPLAN set up a network of quality sites with access to well-characterized clinical specimens and capacity for independent evaluations. The International Committee for Congenital Anomaly Surveillance Tools was formed with global representation from regional networks conducting birth defects surveillance. We have collated a comprehensive inventory of resources and tools for birth defects surveillance, and developed an App for low resource regions facilitating the coding and description of all major externally visible congenital anomalies including congenital Zika syndrome. Research Capacity Network (REDe) is a shared and open resource centre where researchers and health workers can access tools, resources and support, enabling better and more research in the region. Addressing the gap in research capacity in LMICs is pivotal in ensuring broad-based systems to be prepared for the next outbreak. Our shared and open research space through REDe will be used to maximize the transfer of research into practice by summarizing the research output and by hosting the tools, resources, guidance and recommendations generated by these studies. Leveraging on the research from this consortium, we are working towards a research preparedness network.
Keywords
European CommissionGuillain-Barré syndrome
Zika
Birth defect
Congenital Zika syndrome
Encephalitis
Epidemic preparedness
Microcephaly
Research capacity building
Sustainability
DeCS
Síndrome de Guillain-BarréZika virus
Anormalidades Congênitas
Encefalite
Epidemias
Microcefalia
Fortalecimento Institucional
Avaliação de Programas e Projetos de Saúde
Citation
WILDER-SMITH, Annelies et al. ZikaPLAN: addressing the knowledge gaps and working towards a research preparedness network in the Americas. Global Health Action, v. 12, n. 1, p. 1-16, 2019.DOI
10.1080/16549716.2019.1666566ISSN
1654-9716Notes
Celina Maria Turchi Martellie. Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. Ana Maria Bispo de Filipps. Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil. Maria Elisabeth Moreira. Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.aDepartment of Epidemiology and Global Health, Umeå University, Umeå, Sweden; bLondon School of Hygiene & Tropical Medicine, London, UK; cDepartamento de Medicina Tropical, Universidade Federal de Pernambuco, Recife, Brasil; dDepartamento de Medicina Interna, Universidade de Pernambuco, Recife, Brasil; eInstituto Aggeu Magalhães, Fundação Oswaldo Cruz, Recife, Brasil; fDepartamento de Medicina Social, Universidade Federal de Pernambuco, Recife, Brasil; gInstituto de Ciências Biológicas, Universidade de Pernambuco, Recife, Brasil; hInstituto Fernandes Figueira – Fundação Oswaldo Cruz, Rio de Janeiro, Brasil; iInstituto de Patologia Tropical e Saúde Publica, Universidade Federal de Goiás, Goiânia, Brasil; jInstitute of Infection and Global Health, The University of Liverpool, Liverpool, UK; kDepartments of Neurology and Immunology, Erasmus Universitair Medisch Centrum Rotterdam, The Netherlands; lJohns Hopkins University, Baltimore, MD, USA; mUniversidad del Valle, Colombia; nLaboratório de Flavivírus, Instituto Oswaldo Cruz, Brazil; oDepartment of Microbiology, Immunology and Transplantation, KU Leuven, Rega Institute of Medical Research, Leuven, Belgium; pInstitute of Tropical Medicine, Antwerp, Belgium; qInstitute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, UK; rInsitituto Medicina Tropical, Pedro Kouri, Cuba; sDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, NC, USA; tDepartmento del Medicina, Fundacion Universidad del Norte, Barranquilla, Colombia; uDivision of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA; vDepartment of Medicine, University of California San Diego, La Jolla, CA, USA; wInsect-Virus Interactions Unit, Institut Pasteur, UMR2000, CNRS, Paris, France; xMaternal Fetal and Infant Research Centre, Institute of Nursing and Health Research, Ulster University, Newtownabbey, UK; yPopulation Health Research Institute, St George’s, University of London, London, UK; zAssociação Técnico-Científica Estudo Colaborativo Latino Americano de Malformações Congênitas (ECLAMC) no Departmento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; aaHospital Federal dos Servidores do Estado, Rio de Janeiro, Brazil; bbHospital da Restauração, Recife, Brazil; ccOswaldo Cruz Foundation, Recife, Brazil; ddInstituto Butantan, Brazil; eePediatrics Department, Medical School of University of Sao Paulo, Sao Paulo, Brazil; ffThe Global Health Network, Masters and Scholars of the University of Oxford, Oxford, UK; Annelies Wilder-Smith, Raman Preet, Karl-Erik Renhorn, Joacim Rocklöv, Niklas Arnberg, John Kinsman, David Persson, Stefan Nord, Lena Mustonen, Sara Forsberg (#1 Umeå University, Sweden); Elizabeth B. Brickley, Laura C. Rodrigues, Ludmila Lobkowicz, Rosanna Peeling, Debi Boeras, Andrew K. Falconar, Michael Gaunt, Kathleen M O’Reilly, James Logan, Grace Power, Thomas Ant, Laith Yakob, Hannah Kuper, Neal Alexander (#2 London School of Hygiene & Tropical Medicine, UK); Hugh J. Willison, Julia M. Edgar, Susan C. Barnett (#3 University of Glasgow, UK); Trudie Lang, Nina Jamieson, Bonny Baker, Liam Boggs (#4 University of Oxford, UK); Joan K Morris (#5 Queen Mary University of London, UK); Helen Dolk, Leke Aminkeng, Katy Karnell (#6 Ulster University, UK); Johan Neyts, Suzanne Kaptein, Kai Dallmeier (#7 Katholieke Universiteit Leuven, The Netherlands); Bart C. Jacobs, Sonja E. Leonhard, Melissa Mandarakas (#8Erasmus Universitair Medisch Centrum, The Netherlands); Louis Lambrechts, Fabian Aubry (#9 Institut Pasteur, France); Claudia Romero-Vivas (#10 Fundacion Universidad del Norte, Colombia); Carlos Pardo Villamizar, Lyda Osorio (#11 Universidad del Valle, Colombia); Koren Wolman-Tardy, Margaux Lucini, Jason Soffe, Florence Pradel, Sebasitan Quesney, Richard Vaux (#12 Fondation Mérieux, France); Tom Solomon, Suzannah Lant, Louise Cooper, Mike J Griffiths, Lance Turtle, Lisa Ng, Ravi Mehta, Raquel Madialdea-Carrera, (#13 University of Liverpool, UK); Alessandro Sette, Daniela Weiskopf (#14 La Jolla Institute for Allergy and Immunology, USA); Aravinda M. de Silva, Stefan Matz (#15 University of North Carolina at Chapel Hill, USA); Ralph Huits, Kevin K. Ariën, Liselotte Cnops (#16 Prins Leopald Instituut voor Tropische Geneeskunde, Belgium); Eduardo Massad, Esper Kallas, Amilton A Barreira (#17 Fundacao de Apoio a Universidade de Sao Paulo, Brazil); Alexander R. Precioso, Ricardo Palacios Gomez, Beatriz da Costa Thome (#18 Instituto Butantan, Brazil); Ieda Orioli, Daniel Mattos (#19 Associação Técnico-Científica Estudo Colaborativo Latino Americano de Malformações Congênitas (ECLAMC), Brazil); Ana Maria Bispo de Filippis, David Brown, Rafael Freitas de Oliveira Franca, Maria E Moreira, Zilton Vasconselos, Celina M Turchi, Ernesto TA Marques Jr., Wayner V. de Souza (#20 Fundacao Oswaldo Fiocruz, Brazil); Maria G. Guzman, José Luis Pelegrino, Mayling Vera Alvarez, Alicia Reyes Jiménez (#21 Instituto Medicina Tropical Pedro Kouri, Cuba); Amadou A Sall, Cheikh Tidiane Diagne (#22 Institut Pasteur de Dakar, Senegal); Christoph Hatz, Andreas Neumayr; Pie Mueller (#23 Schweizerisches Tropen-und Public Health-Institut, Switzerland); In-Kyu Yoon (#24 International Institute of Vaccine, S Korea); Ricardo A. A. Ximenes, Thália V. Barreto de Araújo, Celina M Turchi Martelli, Demócrito D. B. Miranda-Filho, Ulisses R. Montarroyos, Marília D. Turchi, Luiza Emylce Pelá Rosado (#25 Universidade Federal de Pernambuco, Brazil).
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