Author | Costa, Dirceu Joaquim | |
Author | Favali, Cecilia Beatriz Fiuza | |
Author | Clarêncio, Jorge | |
Author | Afonso, Lilian Maria | |
Author | Conceição, Viviane | |
Author | Miranda, José Carlos | |
Author | Titus, Richard G. | |
Author | Valenzuela, Jesus G. | |
Author | Barral Netto, Manoel | |
Author | Barral, Aldina Maria Prado | |
Author | Brodskyn, Claudia Ida | |
Access date | 2012-03-14T19:59:41Z | |
Available date | 2012-03-14T19:59:41Z | |
Document date | 2004 | |
Citation | COSTA, Dirceu Joaquim et al. Lutzomyia longipalpis salivary gland homogenate impairs cytokine production and costimulatory molecule expression on human monocytes and dendritic cells. InfectIon and Immunity, v. 72, n. 3, p. 1298-1305, Mar. 2004. | pt_BR |
ISSN | 0019-9567 | |
URI | https://www.arca.fiocruz.br/handle/icict/3798 | |
Language | eng | pt_BR |
Rights | open access | pt_BR |
Title | Lutzomyia longipalpis salivary gland homogenate impairs cytokine production and costimulatory molecule expression on human monocytes and dendritic cells | pt_BR |
Type | Article | pt_BR |
DOI | 10.1128/IAI.72.3.1298–1305.2004 | |
Abstract | In this report, we describe an investigation of the effects of Lutzomyia longipalpis sand fly salivary gland homogenates (SGH) on cytokine production and expression of costimulatory molecules on human monocytes, macrophages (Mphis), and dendritic cells (DCs). SGH of L. longipalpis induced an increase in interleukin-6 (IL-6), IL-8 and IL-12p40 production but a decrease in tumor necrosis factor alpha and IL-10 production by lipopolysaccharida (LPS)-stimulated monocytes. We also examined the expression of costimulatory molecules on the surface of monocytes, Mphis, and DCs. Whereas SGH affected the expression of these molecules on monocytes and Mphis, it had little effect on these molecules on DCs. However, when DCs were generated from human monocytes in the presence of SGH, SGH inhibited the expression of costimulatory molecules. In addition, a decrease in the maturation of DCs induced by CD40L was observed in the presence of SGH. Finally, preincubating SGH with human sera containing anti-SGH-specific antibodies abolished the effects of SGH on cytokine production by LPS-stimulated monocytes. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil. | pt_BR |
Affilliation | Colorado State University. College of Veterinary Medicine and Biomedical Sciences. Colorado, USA. | pt_BR |
Affilliation | National Institute of Health. Bethesda, Maryland, USA. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
DeCS | Citocinas | pt_BR |
DeCS | Psychodidae | pt_BR |
DeCS | Glândulas Salivares | pt_BR |
DeCS | Diferenciação Celular | pt_BR |
DeCS | Células Dendríticas | pt_BR |
DeCS | Insetos Vetores | pt_BR |
DeCS | Leishmania | pt_BR |
DeCS | Leishmaniose | pt_BR |
DeCS | Lipopolissacarídeos | pt_BR |
DeCS | Macrófagos | pt_BR |
DeCS | Monócitos | pt_BR |
DeCS | Testes de Neutralização | pt_BR |