Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/3841
Title: Penetration sites and migratory routes of Angiostrongylus costaricensis in the experimental intermediate host (Sarasinula marginata)
Authors: Mendonça, Cristiane Lafetá Furtado de
Carvalho, Omar dos Santos
Mota, Ester Maria
Machado, Marcelo Pelajo
Caputo, Luzia F. G.
Lenzi, Henrique Leonel
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas René-Rachou. Laboratório de Helmintoses Intestinais. Belo Horizonte, MG, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas René-Rachou. Laboratório de Helmintoses Intestinais. Belo Horizonte, MG, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.
Abstract: The intermediate hosts of Angiostrongylus costaricensis are terrestrian molluscs, mostly of the family Veronicellidae. The present work aimed at clarifying more accurately the sites of penetration and the migratory routes of A. costaricensis in the tissue slugs and at verifying the pattern of the perilarval reaction at different times of infection. Slugs were individually infected with 5,000 L1, and killed from 30 min to 30 days after infection. From 30 min up to 2 hr after infection, L1 were found within the lumen of different segments of the digestive tube having their number diminished in more advanced times after exposition until complete disappearance. After 30 min of exposition, percutaneous infection occurred, simultaneously to oral infection. Perilarval reaction was observed from 2 hr of infection around larvae in fibromuscular layer, appearing later (after 6 hr) around larvae located in the viscera. A pre-granulomatous reaction was characterized by gradative concentration of amebocytes around larvae, evolving two well-organized granulomas. In this work we confirmed the simultaneous occurrence of oral and percutaneous infections. Perilarval reaction, when very well developed, defined typical granulomatous structure, including epithelioid cell transformation. The infection also caused a systemic mobilization of amebocytes and provoked amebocyte-endothelium interactions.
Keywords: Angiostrongylus costaricensis
Granuloma
Migratory routes
Amebocytes
Intermediate host
Sarasinula marginata
DeCS: Angiostrongylus
Interações Hospedeiro-Parasita
Moluscos - parasitologia
Infecções por Strongylida
Issue Date: 1999
Publisher: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
Citation: MENDONCA, Cristiane L.G.F. et al. Penetration Sites and Migratory Routes of Angiostrongylus costaricensis in the Experimental Intermediate Host (Sarasinula marginata). Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v.94, n.4, p. 549-556, 1999.
Description: Acknowledgements to A.L. de Amorim, FF Cruz, ID Pedro (Department of Pathology, Instituto Oswaldo Cruz) for their technical assistance.
DOI: 10.1590/S0074-02761999000400022
ISSN: 0074-0276
Copyright: open access
Appears in Collections:MG - IRR - Artigos de Periódicos
IOC - Artigos de Periódicos

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