| Author | Signorini, Dario José Hart Pontes | |
| Author | Oliveira Netto, Ana Maria Schmidt de | |
| Author | Monteiro, Michelle Carreira Miranda | |
| Author | Gabbay, Sergio | |
| Author | Andrade, Marion de Fátima Castro de | |
| Author | Bastos, Francisco Inácio Pinkusfeld Monteiro | |
| Author | Codeço, Cláudia Torres | |
| Access date | 2012-05-02T02:53:30Z | |
| Available date | 2012-05-02T02:53:30Z | |
| Document date | 2011 | |
| Citation | SIGNORINI, Dario José Hart Pontes et al. A Comparison of sonographic assessments and clinical questionnaire in the diagnosis of HIV-associated lipodystrophy. Journal of the International Association of Physicians in AIDS Care, Chicago, v. 10, n. 6, p. 351-356, Nov./Dec. 2011. | en_US |
| ISSN | 1545-1097 | |
| URI | https://www.arca.fiocruz.br/handle/icict/3869 | |
| Language | eng | en_US |
| Publisher | SAGE Publications | en_US |
| Rights | open access | en_US |
| Title | A comparison of sonographic assessments and clinical questionnaire in the diagnosis of HIV-associated lipodystrophy | en_US |
| Type | Article | en_US |
| DOI | 10.1177/1545109711399660 | |
| Abstract | The study evaluated the use of sonographic measurements as an alternative to assessments based on clinical or other imaging techniques for the diagnosis of body-fat abnormalities. The study enrolled 179 HIV-infected patients, 81 (45.3%) of them diagnosed as lipodystrophy (LD)-positive based on a clinical standard questionnaire. Association between clinical LD and sonographic measurements of face, right upper limb, subcutaneous abdomen, and visceral compartments was evaluated by multiple logistic regression. The predicted probability of the logistic model was 0.64, corresponding to a maximum sensitivity of 69.1% (58%-79%), a specificity of 94.9% (88%-98%), and to positive and negative predictive values of 92% (82%-97%) and 79% (70%-86%), respectively. Kappa measure of concordance was 65% (54%-77%). Low sensitivity poses a problem for the use of sonography to detect LD in the clinical routine as a single exam, speaking in favor of the combined use of clinical and sonographic measurements over time. | en_US |
| Affilliation | Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée e Guinle. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Instituto Brasileiro de Ultra-Sonografia. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée e Guinle. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Instituto Brasileiro de Ultra-Sonografia. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Comunicação e Informação Científica e Tecnológica em Saúde. Departamento de Informações em Saúde. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil. | en_US |
| Subject | HIV-associated lipodystrophy syndrome | en_US |
| Subject | Anti-HIV agents | en_US |
| Subject | ROC curve | en_US |
| Subject | Ultrasonography | en_US |
| Subject | Logistic models | en_US |
| Subject | Sensitivity and specificity | en_US |
| DeCS | Síndrome de Lipodistrofia Associada ao HIV/diagnóstico | en_US |
| DeCS | Fármacos Anti-HIV | en_US |
| DeCS | Curva ROC | en_US |
| DeCS | Questionário | en_US |
| DeCS | Modelos Logísticos | en_US |
| DeCS | Sensibilidade e Especificidade | en_US |
