| Author | Marzocchetti, Angela | |
| Author | Lima, Marco | |
| Author | Tompkins, Troy | |
| Author | Kavanagh, Daniel.G | |
| Author | Gandhi, Rajesh T. | |
| Author | O'Neill, David W. | |
| Author | Bhardwaj, Nina | |
| Author | Koralnik, Igor J. | |
| Access date | 2019-12-23T13:30:13Z | |
| Available date | 2019-12-23T13:30:13Z | |
| Document date | 2009 | |
| Citation | MARZOCCHETTI, Angela et al. Efficient in vitro expansion of JC virus-specific CD8+ T-cell responses by JCV peptide-stimulated dendritic cells from patients with progressive multifocal leukoencephalopathy. Virology, v. 383, n. 2, p. 173-177, Jan. 2009. | pt_BR |
| ISSN | 0042-6822 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/38791 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | pt_BR |
| Title | Efficient in vitro expansion of JC virus-specific CD8+ T-cell responses by JCV peptide-stimulated dendritic cells from patients with progressive multifocal leukoencephalopathy | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1016/j.virol.2008.10.046 | |
| Abstract | Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the brain caused by JC virus (JCV) for which there is no cure. PML patients who have JCV-specific CD8+ cytotoxic T lymphocytes (CTL) in their blood have a better clinical outcome. We compared JCV-specific CTL responses in vitro elicited either by JCV peptide-loaded dendritic cells (DC) or by direct peptide stimulation of lymphocytes from 20 HLA A*0201+ healthy controls, HIV+ and PML patients. JCV peptide-loaded DC elicited a stronger CTL expansion in 13/15 responders. DC can induce potent JCV-specific CTL response in vitro, and may constitute a promising approach for PML immunotherapy. | pt_BR |
| Affilliation | Harvard Medical School. Beth Israel Deaconess Medical Center. Division of Viral Pathogenesis. Boston, MA, USA. | pt_BR |
| Affilliation | Harvard Medical School. Beth Israel Deaconess Medical Center. Department of Neurology. Boston, MA, USA / Harvard Medical School. Beth Israel Deaconess Medical Center. Division of Viral Pathogenesis. Boston, MA, USA / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Harvard Medical School. Beth Israel Deaconess Medical Center. Division of Viral Pathogenesis. Boston, MA, USA. | pt_BR |
| Affilliation | Harvard Medical School. Massachusetts General Hospital. Partners AIDS Research Center. Boston, MA, USA. | pt_BR |
| Affilliation | Harvard Medical School. Massachusetts General Hospital. Partners AIDS Research Center. Boston, MA, USA. | pt_BR |
| Affilliation | New York University. School of Medicine. New York, NY, USA. | pt_BR |
| Affilliation | New York University. School of Medicine. New York, NY, USA. | pt_BR |
| Affilliation | Harvard Medical School. Beth Israel Deaconess Medical Center. Department of Neurology. Boston, MA, USA / Harvard Medical School. Beth Israel Deaconess Medical Center. Division of Viral Pathogenesis. Boston, MA, USA. | pt_BR |
| Subject | JC virus | pt_BR |
| Subject | Progressive multifocal leukoencephalopathy | pt_BR |
| Subject | Dendritic cells | pt_BR |
