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DIRECTLY OBSERVED THERAPY AND RISK OF UNFAVOURABLE TUBERCULOSIS TREATMENT OUTCOMES AMONG AN INTERNATIONAL COHORT OF PEOPLE LIVING WITH HIV IN LOW- AND MIDDLE-INCOME COUNTRIES
Pettit, April C et al. | Date Issued: 2019
Author
Pettit, April C
Jenkins, Cathy A
Blevins Peratikos, Meridith
Yotebieng, Marcel
Diero, Lameck
Do, Cuong D
Ross, Jeremy
Veloso,Valdiléa G.
Hawerlander, Denise
Marcy, Olivier
Shepherd, Bryan E
Fenner, Lukas
Sterling, Timothy R
International Epidemiology Databases to Evaluate AIDS (IeDEA) Consortium
Affilliation
Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA./ Vanderbilt Tuberculosis Center, Nashville, TN, USA.
Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
College of Public Health, The Ohio State University, Columbus, OH, USA.
Academic Model Providing Access To Healthcare (AMPATH), Eldoret, Kenya.
Bach Mai Hospital, Hanoi, Vietnam.
TREAT Asia/amfAR - The Foundation for AIDS Research, Bangkok, Thailand.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
Centre Intégré de Recherches Biocliniques d'Abidjan CIRBA, Abidjan, Côte d'Ivoire.
Centre INSERM U1219, Bordeaux Population Health, University of Bordeaux, Bordeaux, France.
Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA./ Vanderbilt Tuberculosis Center, Nashville, TN, USA.
Abstract
Identification of persons living with human immunodeficiency virus (HIV)-associated tuberculosis (TB) at increased risk for unfavourable TB outcomes would inform efforts to improve such outcomes. We sought to identify factors associated with a decreased risk of unfavourable TB treatment outcomes among people living with HIV-infection (PLHIV) in low- and middle-income countries (LMIC), with a specific focus on directly observed therapy (DOT) compared with self-administered therapy (SAT) during the continuation phase of anti-TB therapy.
Keywords
Antiretroviral therapy
Body mass index
Directly observed therapy
Human immunodeficiency virus infection
Tuberculosis
 
Publisher
Wiley
Citation
PETTIT, April C. et al. Directly observed therapy and risk of unfavourable tuberculosis treatment outcomes among an international cohort of people living with HIV in low- and middle-income countries. Journal of the International AIDS Society, v. 22, n. 12, p. e25423, 2019.
DOI
10.1002/jia2.25423
ISSN
1758-2652
Notes
The International Epidemiology Databases to Evaluate AIDS (IeDEA) Collaboration is an international research consortium established in 2006 by the National Institute of Allergy and Infectious Diseases to provide a rich resource for globally diverse HIV/AIDS data.