| Author | Cacere, Camila R. | |
| Author | Mendes-Giannini, Maria J. S. | |
| Author | Valle, Antonio Carlos Francesconi do | |
| Author | Duarte, Alberto J. S. | |
| Author | Benard, Gil | |
| Access date | 2019-12-26T14:11:59Z | |
| Available date | 2019-12-26T14:11:59Z | |
| Document date | 2009 | |
| Citation | CACERE, Camila R. et al. Altered ex vivo expression of caspase 8, caspase 9, and Bcl-2 is associated with T-cell hyporeactivity in patients with paracoccidioidomycosis. Clinical and Vaccine Immunology, v. 16, n. 6, p. 953-955, June 2009. | pt_BR |
| ISSN | 1556-6811 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/38839 | |
| Language | eng | pt_BR |
| Publisher | American Society for Microbiology | pt_BR |
| Rights | open access | pt_BR |
| Title | Altered ex vivo expression of caspase 8, caspase 9 and Bcl-2 is associated with the T-cell hyporreactivity of paracoccidioidomycosis patients | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1128/CVI.00071-09 | |
| Abstract | To better understand the T-cell hyporesponsiveness of patients with paracoccidioidomycosis, we tested the
hypothesis that the T cells were committed to apoptosis. We show here that T cells of patients with paracoccidioidomycosis overexpress caspase 9 and caspase 8 but express low Bcl-2 levels and that interleukin-2 was unable to revert the hyporesponsiveness. These data suggest that the T cells would in vivo be driven to a tolerant state and apoptosis. | pt_BR |
| Affilliation | University of São Paulo. Medical School. Laboratory of Dermatology and Immunodeficiencies. São Paulo, SP, Brazil. | pt_BR |
| Affilliation | São Paulo State University. Faculty of Pharmaceutical Sciences. Clinical Pathology Department. Araraquara, SP, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | University of São Paulo. Medical School. Laboratory of Dermatology and Immunodeficiencies. São Paulo, SP, Brazil. | pt_BR |
| Affilliation | University of São Paulo. Medical School. Laboratory of Dermatology and Immunodeficiencies. São Paulo, SP, Brazil / University of São Paulo. Medical School. Clinics Hospital. Division of Infectious Diseases. Systemic Mycoses Outpatient Unit. São Paulo, SP, Brazil. | pt_BR |
| Subject | Paracoccidioidomycosis | pt_BR |
| Subject | T-cell | pt_BR |
| e-ISSN | 1556-679X | |
