Altered ex vivo expression of caspase 8, caspase 9 and Bcl-2 is associated with the T-cell hyporreactivity of paracoccidioidomycosis patients

University of São Paulo. Medical School. Laboratory of Dermatology and Immunodeficiencies. São Paulo, SP, Brazil.
São Paulo State University. Faculty of Pharmaceutical Sciences. Clinical Pathology Department. Araraquara, SP, Brazil.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.
University of São Paulo. Medical School. Laboratory of Dermatology and Immunodeficiencies. São Paulo, SP, Brazil.
University of São Paulo. Medical School. Laboratory of Dermatology and Immunodeficiencies. São Paulo, SP, Brazil / University of São Paulo. Medical School. Clinics Hospital. Division of Infectious Diseases. Systemic Mycoses Outpatient Unit. São Paulo, SP, Brazil.

Abstract

To better understand the T-cell hyporesponsiveness of patients with paracoccidioidomycosis, we tested the hypothesis that the T cells were committed to apoptosis. We show here that T cells of patients with paracoccidioidomycosis overexpress caspase 9 and caspase 8 but express low Bcl-2 levels and that interleukin-2 was unable to revert the hyporesponsiveness. These data suggest that the T cells would in vivo be driven to a tolerant state and apoptosis.

Keywords

Paracoccidioidomycosis
T-cell

Publisher

American Society for Microbiology

Citation

CACERE, Camila R. et al. Altered ex vivo expression of caspase 8, caspase 9, and Bcl-2 is associated with T-cell hyporeactivity in patients with paracoccidioidomycosis. Clinical and Vaccine Immunology, v. 16, n. 6, p. 953-955, June 2009.

DOI

10.1128/CVI.00071-09

ISSN

1556-6811

Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/38839

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