| Author | Duarte, Rafael Silva | |
| Author | Lourenço, Maria Cristina Silva | |
| Author | Fonseca, Leila de Souza | |
| Author | Leao, Sylvia Cardoso | |
| Author | Amorim, Efigenia de Lourdes T. | |
| Author | Rocha, Ingrid L. L. | |
| Author | Coelho, Fabrice Santana | |
| Author | Viana-Niero, Cristina | |
| Author | Gomes, Karen Machado | |
| Author | Silva, Marlei Gomes da | |
| Author | Lorena, Nádia Suely de Oliveira | |
| Author | Pitombo, Marcos Bettini | |
| Author | Ferreira, Rosa M. C. | |
| Author | Garcia, Márcio Henrique de Oliveira | |
| Author | Oliveira, Gisele Pinto de | |
| Author | Lupi, Otilia | |
| Author | Vilaca, Bruno Rios | |
| Author | Serradas, Lúcia Rodrigues | |
| Author | Chebabo, Alberto | |
| Author | Marques, Elizabeth Andrade | |
| Author | Teixeira, Lúcia Martins | |
| Author | Dalcolmo, Margareth | |
| Author | Senna, Simone Gonçalves | |
| Author | Sampaio, Jorge Luiz Mello | |
| Access date | 2019-12-26T15:20:54Z | |
| Available date | 2019-12-26T15:20:54Z | |
| Document date | 2009 | |
| Citation | DUARTE, Rafael Silva et al. Epidemic of postsurgical infections caused by Mycobacterium massiliense. Journal of Clinical Microbiology, v. 47, n. 7, p. 2149-2155, July 2009. | pt_BR |
| ISSN | 0095-1137 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/38846 | |
| Language | eng | pt_BR |
| Publisher | American Society for Microbiology | pt_BR |
| Rights | open access | pt_BR |
| Title | Epidemic of postsurgical infections caused by Mycobacterium massiliense | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1128/JCM.00027-09 | |
| Abstract | An epidemic of infections after video-assisted surgery (1,051 possible cases) caused by rapidly growing
mycobacteria (RGM) and involving 63 hospitals in the state of Rio de Janeiro, Brazil, occurred between August
2006 and July 2007. One hundred ninety-seven cases were confirmed by positive acid-fast staining and/or
culture techniques. Thirty-eight hospitals had cases confirmed by mycobacterial culture, with a total of 148
available isolates recovered from 146 patients. Most (n 144; 97.2%) isolates presented a PRA-hsp65
restriction pattern suggestive of Mycobacterium bolletii or Mycobacterium massiliense. Seventy-four of these
isolates were further identified by hsp65 or rpoB partial sequencing, confirming the species identification as M.
massiliense. Epidemic isolates showed susceptibility to amikacin (MIC at which 90% of the tested isolates are
inhibited [MIC90], 8 g/ml) and clarithromycin (MIC90, 0.25 g/ml) but resistance to ciprofloxacin (MIC90,
>32 g/ml), cefoxitin (MIC90, 128 g/ml), and doxycycline (MIC90, >64 g/ml). Representative epidemic M.
massiliense isolates that were randomly selected, including at least one isolate from each hospital where
confirmed cases were detected, belonged to a single clone, as indicated by the analysis of pulsed-field gel
electrophoresis (PFGE) patterns. They also had the same PFGE pattern as that previously observed in two
outbreaks that occurred in other Brazilian cities; we designated this clone BRA100. All five BRA100 M.
massiliense isolates tested presented consistent tolerance to 2% glutaraldehyde. This is the largest epidemic of
postsurgical infections caused by RGM reported in the literature to date in Brazil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal de São Paulo. Departamento de Microbiologia, Imunologia e Parasitologia. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Sérgio Franco Medicina Diagnóstica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Sérgio Franco Medicina Diagnóstica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade do Estado do Rio de Janeiro. Hospital Universitário Pedro Ernesto. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal de São Paulo. Departamento de Microbiologia, Imunologia e Parasitologia. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Ministério da Saúde. Secretaria de Vigilância em Saúde. Brasília, DF, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Estudos de Saúde Coletiva. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Secretaria Municipal de Saúde do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital de Clínicas Riomar. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Centro de Referência Professor Hélio Fraga. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Fleury de Ensino e Pesquisa. São Paulo, SP, Brasil. | pt_BR |
| Subject | Mycobacterium massiliense | pt_BR |
| Subject | Epidemic of postsurgical infections | pt_BR |
| e-ISSN | 1098-660X | |
| Embargo date | 2020-06-26 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
