| Author | Bidau, Claudio J. | |
| Author | Amat, Aníbal G. | |
| Author | Yajia, Marta E. | |
| Author | Marti, Dardo A. | |
| Author | Gimenez, Mabel D. | |
| Author | Riglos, Ana G. | |
| Author | Silvestroni, Aurelio | |
| Author | Torres, Guillermo M. | |
| Author | Fumagalli, Emiliano | |
| Access date | 2020-01-01T17:59:04Z | |
| Available date | 2020-01-01T17:59:04Z | |
| Document date | 2006 | |
| Citation | BIDAU, Claudio J. et al. Evaluation of Cytotoxic and Mitodepressive Activity of Aqueous Extracts from Thirteen Argentine Medicinal Plants. Acta Farmaceutica Bonaerense, Buenos Aires, v. 25, n. 4, p. 555-559, 2006. | pt_BR |
| ISSN | 0326-2383 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/38923 | |
| Description | CJB is a memeber of the CONICET Researcher Career (Argentina) and is grateful the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) of Brazil and Fundação Oswaldo Cruz (FIOCRUZ) of Rio de
Janeiro for a visiting Professorship that allowed the completion of this paper. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Colegio de Farmacéuticos. Departamento Científico | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Plantas medicinais | pt_BR |
| Subject in Portuguese | Medicina popular | pt_BR |
| Subject in Portuguese | Missões | pt_BR |
| Subject in Portuguese | Extratos aquosos | pt_BR |
| Subject in Portuguese | Atividade citotóxica | pt_BR |
| Title | Evaluation of Cytotoxic and Mitodepressive Activity of Aqueous Extracts from Thirteen Argentine Medicinal Plants | pt_BR |
| Type | Article | |
| Abstract | Thirteen vascular plant species used in argentine folk medicine were studied in order to evaluate the cytotoxic and mitodepressive activity of their aqueous extracts at different concentrations, using both the Artemia salinaTest and the AlliumTest. No cytotoxic activity was observed for analyzed extracts with the Artemia salinaTest, and in relation to macroscopic parameters of general toxicity, all species exhibited negative albeit non-significant correlations between average root length and extract concentration in the Allium Test. Frequency of root macroscopic abnormalities and average root length showed significant or highly significant negative correlations in all but two of the analyzed species which nevertheless exhibited comparable negative trends, indicating a concentration effect. In almost all assayed samples a Cmitotic effects of the extracts was observed since the mitotic index decreased and mitotic abnormalities increased with increasing extract concentrations. Clastogenic activity was not found in the analyzed extracts. | pt_BR |
| xmlui.metadata.dc.description.abstractes | Evaluación de la Actividad Citotóxica y Mitodepresiva de Extractos Acuosos de Trece Plantas Medicinales Argentinas”. Trece especies de plantas vasculares usadas en la medicina popular argentina, fueron estudiadas para evaluar las actividades citotóxicas y mitodepresivas de sus extractos acuosos a diferentes concentraciones usando los tests de Artemia salina yAllium.No se observó actividad citotóxica de los extractos analizados con el test de Artemia salinay, en relación a los parámetros macroscópicos de toxicidad general, todas las especies mostraron correlaciones negativas aunque no significativas entre la longitud media de las raíces y la concentración del extracto y el test de Allium. La frecuencia de las anormalidades macroscópicas de las raíces mostró correlaciones negativas en todas las especies analizadas siendo la mayoría, estadísticamente significativas, indicando un efecto de la concentración. En casi todas las muestras ensayadas, se observaron efectos de tipo C-mitótico ya que el Indice Mitótico disminuyó en tanto que las anormalidades mitóticas se incrementaron con las concentraciones crecientes de los extractos. En ningún caso se observó actividad clastogénica significativa. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Laboratório de Biologia e Controle da Esquistossomose. Rio de Janeiro, RJ, Brasil / CONICET. | pt_BR |
| Affilliation | Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales. Misiones, Argentina. | pt_BR |
| Affilliation | Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales. Misiones, Argentina. | pt_BR |
| Affilliation | CONICET / Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales. Misiones, Argentina. | pt_BR |
| Affilliation | Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales. Misiones, Argentina. | pt_BR |
| Affilliation | Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales. Misiones, Argentina. | pt_BR |
| Affilliation | Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales. Misiones, Argentina. | pt_BR |
| Affilliation | Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales. Misiones, Argentina. | pt_BR |
| Subject | AlliumTest | pt_BR |
| Subject | Aqueous extracts | pt_BR |
| Subject | Artemia salinaTest | pt_BR |
| Subject | C-mitotic activity | pt_BR |
| Subject | Cytotoxic activity | pt_BR |
| Subject | Folk medicine | pt_BR |
| Subject | Genotoxic activity | pt_BR |
| Subject | Medicinal plants | pt_BR |
| Subject | Misiones | pt_BR |
| Subject in Spanish | Actividad citotóxica | pt_BR |
| Subject in Spanish | Actividad C-mitótica | pt_BR |
| Subject in Spanish | Actividad genotóxica | pt_BR |
| Subject in Spanish | Argentina | pt_BR |
| Subject in Spanish | Extractos acuosos | pt_BR |
| Subject in Spanish | Medicina popular | pt_BR |
| Subject in Spanish | Plantas medicinales | pt_BR |
| Subject in Spanish | Test de Allium | pt_BR |
| Subject in Spanish | Test de Artemia salina | pt_BR |
| Subject in Spanish | Misiones | pt_BR |
