Author | Costa, Emmanoel Vilaça | |
Author | Pinheiro, Maria Lúcia B. | |
Author | Xavier, Clahildek M. | |
Author | Silva, Jefferson R. A. | |
Author | Amaral, Ana Cláudia F. | |
Author | Souza, Afonso D. L. | |
Author | Barison, Andersson | |
Author | Campos, Francinete R. | |
Author | Ferreira, Antonio G. | |
Author | Machado, Gérzia M. C. | |
Author | Leon, Leonor L. P. | |
Access date | 2020-01-03T15:46:56Z | |
Available date | 2020-01-03T15:46:56Z | |
Document date | 2006 | |
Citation | COSTA, Emmanoel Vilaça et al. A Pyrimidine-â-carboline and Other Alkaloids from Annona foetida with Antileishmanial Activity. Journal of Natural Products, v. 69, p. 292-294, 2006. | pt_BR |
ISSN | 0163-3864 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/38972 | |
Language | eng | pt_BR |
Publisher | American Chemical Society | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Alcalóides | pt_BR |
Subject in Portuguese | Atividade antileishmanial | pt_BR |
Subject in Portuguese | Leishmania braziliensis | pt_BR |
Title | A Pyrimidine-â-carboline and Other Alkaloids from Annona foetida with Antileishmanial Activity | pt_BR |
Type | Article | pt_BR |
DOI | 10.1021/np050422s | |
Abstract | Bioassay-guided fractionation of the bark extract of Annona foetida afforded a new antileishmanial pyrimidine-â-carboline alkaloid, N-hydroxyannomontine (1), together with the previously reported annomontine (2), O-methylmoschatoline (3), and liriodenine (4). The structure of compound 1 was established on the basis of extensive 1D and 2D NMR and MS analyses. This is the third reported pyrimidine-â-carboline-type alkaloid and is particularly important for Annona genus chemotaxonomy. In addition, all compounds exhibit in vitro antileishmanial activity against promastigote forms of Leishmania braziliensis. Compounds 2 and 4 showed better activity than compounds 1 and 3 against L. braziliensis. Compound 2 was not active against L. guyanensis. | pt_BR |
Affilliation | Universidade Federal do Amazonas. Departamento de Química. Coroado, Manaus, AM. | pt_BR |
Affilliation | Universidade Federal do Amazonas. Departamento de Química. Coroado, Manaus, AM. | pt_BR |
Affilliation | Universidade Federal do Amazonas. Departamento de Química. Coroado, Manaus, AM. | pt_BR |
Affilliation | Universidade Federal do Amazonas. Departamento de Química. Coroado, Manaus, AM. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Departamento de Produtos Naturais. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Amazonas. Departamento de Química. Coroado, Manaus, AM. | pt_BR |
Affilliation | Universidade Federal de São Carlos. São Carlos, SP, Brasil. | pt_BR |
Affilliation | Universidade Federal de São Carlos. São Carlos, SP, Brasil. | pt_BR |
Affilliation | Universidade Federal de São Carlos. São Carlos, SP, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Alkaloids | pt_BR |
Subject | Annona foetida | pt_BR |
Subject | Antileishmanial Activity | pt_BR |
Subject | Pyrimidine-â-carboline | pt_BR |
e-ISSN | 1520-6025 | |