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ESSENTIAL OILS FROM TWO LANTANA SPECIES WITH ANTIMYCOBACTERIAL ACTIVITY
Julião, Lisieux de Santana et al. | Date Issued: 2009
Author
Julião, Lisieux de Santana
Bizzo, Humberto R.
Souza, Andressa M.
Lourenço, Maria Cristina S.
Silva, Pedro Eduardo A.
Tavares, Eliana S.
Rastrelli, Luca
Leitão, Suzana Guimarães
Affilliation
Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Programa de Biotecnologia Vegetal. Rio de Janeiro, RJ, Brasil.
Embrapa Agroindústria de Alimentos. Rio de Janeiro, RJ, Brasil.
Embrapa Agroindústria de Alimentos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Bacteriologia e Bioensaios em Micobactérias. Plataforma de Bioensaios II. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio Grande. Laboratório de Micobactérias. Rio Grande, RS, Brasil.
Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Programa de Biotecnologia Vegetal. Rio de Janeiro, RJ, Brasil.
Università degli Studi di Salerno. Dipartimento di Scienze Farmaceutiche. Fisciano, Italy.
Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Departamento de Produtos Naturais e Alimentos. Rio de Janeiro, RJ, Brasil.
Abstract
Lantana trifolia L. and L. fucata Lindl. are two Brazilian species used in folk medicine for the treatment of respiratory disorders. The composition of the essential oils from the leaves was investigated, as well as their in vitro activity against Mycobacterium tuberculosis. L. trifolia yielded an oil (0.2%) rich in sesquiterpenes. The major substances found were germacrene D (45.1%), (E)-caryophyllene (12.8%), bicyclogermacrene (12.7%) and α-humulene (4.4%). Sesquiterpenes were also the main components of the oil of L. fucata (0.3% yield), the principal ones being β-elemene (27.1%), germacrene D (11.6%), (E)-caryophyllene (7.7%), valencene (5.7%) and germacrene A (4.6%). Both oils exhibited in vitro antimycobacterial activity by the MABA assay with MICs of 80 μg/mL for L. trifolia and 100 μg/mL for L. fucata.
Keywords
Lantana trifolia L.
Lantana fucata Lindl.
Essential oil
MABA
Mycobacterium tuberculosis
Tuberculosis
Verbenaceae
 
Publisher
SAGE Publications
Citation
JULIÃO, Lisieux de Santana et al. Essential oils from two Lantana species with antimycobacterial activity. Natural Product Communications, v. 4, n. 12, p. 1733-1736, 2009.
DOI
10.1177/1934578X0900401224
ISSN
1934-578X