| Author | Lessa, Marcos Adriano | |
| Author | Tibiriçá, Eduardo | |
| Access date | 2020-01-21T13:31:11Z | |
| Available date | 2020-01-21T13:31:11Z | |
| Document date | 2006 | |
| Citation | LESSA, Marcos Adriano; TIBIRIÇÁ, Eduardo. Pharmacologic evidence for the involvement of central and peripheral opioid receptors in the cardioprotective effects of fentanyl. Anesthesia & Analgesia, v. 103, n. 4, p. 815-821, Oct. 2006. | pt_BR |
| ISSN | 0003-2999 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/39348 | |
| Language | eng | pt_BR |
| Publisher | Lippincott, Williams & Wilkins | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Evidência farmacológica | pt_BR |
| Subject in Portuguese | Receptores de opióides periféricos | pt_BR |
| Subject in Portuguese | Efeitos no sistema cardioprotetor | pt_BR |
| Subject in Portuguese | Fentanil | pt_BR |
| Title | Pharmacologic evidence for the involvement of central and peripheral opioid receptors in the cardioprotective effects of fentanyl | pt_BR |
| Type | Article | |
| DOI | 10.1213/01.ane.0000237284.30817.f6 | pt_BR |
| Abstract | BACKGROUND: We investigated the involvement of central and peripheral opioid receptors (OR) in the cardioprotective effects of fentanyl (FENT) in a model of myocardial ischemia/reperfusion injury associated with pharmacologically induced sympathetic overactivity in anesthetized rabbits. METHODS: Central sympathetic stimulation was achieved through intracerebroventricular injection of l-glutamate in animals submitted to 35 min of coronary occlusion followed by 120 min of reperfusion. Rabbits received naloxone HCl intracerebroventricularly or naloxone methiodide IV, a quaternary compound that does not cross the blood–brain barrier, 5 min before FENT treatment (5 or 50μg/kg, IV). RESULTS: Infarct area was reduced only by FENT 50 (from 51% ± 2% to 24% ± 2%). This protective effect was abolished by peripheral (42% ± 4%), but not central, OR blockade (32% ± 3%). The number of premature ventricular complexes during the ischemic period (54 ± 3) was reduced by FENT 50 (19 ± 7), an effect blunted by central (40 ± 3) but not peripheral (18 ± 7) blockade of OR. During reperfusion, the number of premature ventricular complexes (134 ± 50) was reduced to 9 ± 5 by FENT 50 and was prevented by central (42 ± 4) as well as peripheral (20 ± 11) OR blockade. The mortality rate (50%) and incidence of ventricular tachycardia (55%) were completely abolished by FENT 50. CONCLUSIONS: We conclude that fentanyl’s effects for limiting myocardial ischemic injury are mediated via peripheral ORs while opioid’s antiarrhythmic actions are mediated via central OR agonism. | en |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Pharmacologic evidence | pt_BR |
| Subject | Peripheral opioid receptors | pt_BR |
| Subject | Cardioprotective effects | pt_BR |
| Subject | Fentanyl | pt_BR |
| e-ISSN | 1526-7598 | pt_BR |
| Embargo date | 2022-01-01 | |
