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THE ASSOCIATION OF COGNITIVE PERFORMANCE AND IL-6 LEVELS IN SCHIZOPHRENIA IS INFLUENCED BY AGE AND ANTIPSYCHOTIC TREATMENT
Santos, Rafael Ribeiro et al. | Date Issued: 2019
Author
Santos, Rafael Ribeiro
Campos, Carli Salviana Maria de
Ferretjans, Rodrigo
Carvalho, Andrea Teixeira de
Martins Filho, Olindo Assis
Teixeira, Antonio Lucio
Salgado, João Vinicius
Affilliation
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Programa de Neurociência. Belo Horizonte, MG, Brasil.
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Programa de Neurociência. Belo Horizonte, MG, Brasil.
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Programa de Neurociência. Belo Horizonte, MG, Brasil.
Fundação Oswaldo Cruz. Instituto Rene Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brasil.
Fundação Oswaldo Cruz. Instituto Rene Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brasil.
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Programa de Neurociência. Belo Horizonte, MG, Brasil / Santa Casa BH Ensino e Pesquisa. Belo Horizonte, MG, Brasil.
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Programa de Neurociência. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Belo Horizonte, MG, Brasil / Estado de Minas Gerais. Fundação Hospitalar. Hospital Psiquiátrico Raul Soares. Belo Horizonte, MG, Brasil.
Abstract
Aims: Recent findings suggest that cognitive impairment can be associated with inflammation and immune changes in schizophrenia. We aimed to study possible associations between cytokine levels and cognitive performance in a sample of patients with schizophrenia.Methods: Cognition was assessed with the brief assessment of cognition in schizophrenia in 63 clinically stable outpatients with schizophrenia. Blood was collected and cytokines (IL-2, IL-4, IL-6, IL-10, IL-17A, TNF-α, IFN-γ) were measured by cytometric bead array method. Psychopathological scales were also applied.Results: IL-6 correlated negatively with general cognitive performance (rho = -0.395, p = .017) and positively with antipsychotic dose (rho = 0.412, p = .004). Multiple regression analysis showed that cognitive performance is associated with age and antipsychotic dose (p = .000 and p = .033).Conclusion: The association between IL-6 levels and cognitive performance is dependent on age and antipsychotic dose.
Keywords
IL-6
Schizophrenia
Cognition
Inflammation
 
Publisher
Informa Healthcare
Citation
SANTOS, Rafael Ribeiro et al. The association of cognitive performance and IL-6 levels in schizophrenia is influenced by age and antipsychotic treatment. Nordic Journal of Psychiatry, v. 18, p. 1-7, 2019.
DOI
10.1080/08039488.2019.1688389
ISSN
0803-9488